SDC2
Gene Information
- Official Symbol: SDC2
- Official Name: syndecan 2
- Aliases and Previous Symbols: N/A
- Entrez ID: 6383
- UniProt: P34741
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Cell surface proteoglycan that bears heparan sulfate. Regulates dendritic arbor morphogenesis (By similarity). {ECO:0000250}.
Pfam Domains GO Terms
Pfam Domains
| Syndecan |
GO Terms
| dendrite morphogenesis |
| glycosaminoglycan catabolic process |
| aminoglycan catabolic process |
| ephrin receptor signaling pathway |
| PDZ domain binding |
| regulation of dendrite morphogenesis |
| lysosomal lumen |
| Golgi lumen |
| dendrite development |
| retinoid metabolic process |
| glycosaminoglycan biosynthetic process |
| aminoglycan biosynthetic process |
| diterpenoid metabolic process |
| terpenoid metabolic process |
| isoprenoid metabolic process |
| regulation of dendrite development |
| glycosaminoglycan metabolic process |
| aminoglycan metabolic process |
| carbohydrate derivative catabolic process |
| endoplasmic reticulum lumen |
| regulation of cell morphogenesis involved in differentiation |
| post-translational protein modification |
| collagen-containing extracellular matrix |
| leukocyte migration |
| cell morphogenesis involved in neuron differentiation |
| neuron projection morphogenesis |
| plasma membrane bounded cell projection morphogenesis |
| cell projection morphogenesis |
| regulation of cell morphogenesis |
| regulation of neuron projection development |
| transmembrane receptor protein tyrosine kinase signaling pathway |
| cell part morphogenesis |
| cell morphogenesis involved in differentiation |
| cell surface |
| carbohydrate derivative biosynthetic process |
| regulation of neuron differentiation |
| neuron projection development |
| regulation of plasma membrane bounded cell projection organization |
| regulation of cell projection organization |
| enzyme linked receptor protein signaling pathway |
| cell morphogenesis |
| neuron development |
| regulation of neurogenesis |
| cellular component morphogenesis |
| regulation of nervous system development |
| regulation of cell development |
| cellular lipid metabolic process |
| cell migration |
| neuron differentiation |
| carbohydrate derivative metabolic process |
| macromolecule catabolic process |
| regulation of anatomical structure morphogenesis |
| organonitrogen compound catabolic process |
| identical protein binding |
| localization of cell |
| cell motility |
| plasma membrane bounded cell projection organization |
| cell projection organization |
| lipid metabolic process |
| locomotion |
| organonitrogen compound biosynthetic process |
| generation of neurons |
| movement of cell or subcellular component |
| neurogenesis |
| cell development |
| macromolecule biosynthetic process |
| organic substance catabolic process |
| regulation of cell differentiation |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Thalidomide 20μM R07 exp406 | -1.92 |
| ETC-159 50μM R08 exp480 | 1.81 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 17868
- Expression level (log2 read counts): -6.6
Expression Distribution
SDC2 Expression in NALM6 Cells: -6.6
