SLC12A2

Entrez Summary: The protein encoded by this gene mediates sodium and chloride transport and reabsorption. The encoded protein is a membrane protein and is important in maintaining proper ionic balance and cell volume. This protein is phosphorylated in response to DNA damage. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jan 2012].
UniProt Summary: Electrically silent transporter system. Mediates sodium and chloride reabsorption. Plays a vital role in the regulation of ionic balance and cell volume.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
NFN1 1μM R03 exp100	-2.3
UNC2400 2μM R03 exp156	-2.1
proTAME 5μM R04 exp187	-1.72
Bortezomib 0.005μM R00 exp6	1.74
42°C R08 exp539	1.76
Ammonium tetrathiomolybdate 10μM R08 exp448	1.82
Etoposide 0.1μM R05 exp198	2
BI-6727 0.0125μM R03 exp97	2.14
I-BRD9 4μM R07 exp365	2.17
CB-5083 0.4μM R08 exp468	2.18
Milciclib 2μM R08 exp502	2.22
LY2090314 0.003μM R08 exp500 no dilution day6	2.91
LY2090314 0.003μM R08 exp499	3.1
MLN-4924 0.2μM R00 exp21	5.43

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution