SLC22A3

Entrez Summary: N/A
UniProt Summary: Mediates potential-dependent transport of a variety of organic cations. May play a significant role in the disposition of cationic neurotoxins and neurotransmitters in the brain. {ECO:0000269|PubMed:10196521, ECO:0000269|PubMed:10966924}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
THZ531 0.225μM R08 exp444	-2.18
Apcin 25μM plus proTAME 2μM R04 exp177	-2.12
TGF-beta1 44ng/ml R08 exp528	-1.93
MLN-4924 0.2μM R00 exp21	-1.92
BI-D1870 2μM R04 exp162	-1.77
Hippuristanol 0.12μM R08 exp489 no dilution day6	-1.76
RO-3306 3 to 4μM on day4 R04 exp165	-1.73

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution