SNCB
Gene Information
- Official Symbol: SNCB
- Official Name: synuclein beta
- Aliases and Previous Symbols: N/A
- Entrez ID: 6620
- UniProt: Q16143
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene encodes a member of a small family of proteins that inhibit phospholipase D2 and may function in neuronal plasticity. The encoded protein is abundant in lesions of patients with Alzheimer disease. A mutation in this gene was found in individuals with dementia with Lewy bodies. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015].
- UniProt Summary: Non-amyloid component of senile plaques found in Alzheimer disease. Could act as a regulator of SNCA aggregation process. Protects neurons from staurosporine and 6-hydroxy dopamine (6OHDA)-stimulated caspase activation in a p53/TP53- dependent manner. Contributes to restore the SNCA anti-apoptotic function abolished by 6OHDA. Not found in the Lewy bodies associated with Parkinson disease.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 8515
- Expression level (log2 read counts): -4.01
SNCB Expression in NALM6 Cells: -4.01
