UniProt Summary: Metalloreductase that has the ability to reduce both Fe(3+) to Fe(2+) and Cu(2+) to Cu(1+). Uses NAD(+) as acceptor (By similarity). {ECO:0000250}.
Pfam DomainsGO Terms
Pfam Domains
Ferric reduct
F420 oxidored
GO Terms
cupric reductase activity
iron ion import across cell outer membrane
ferric-chelate reductase (NADPH) activity
copper ion import
iron ion transmembrane transport
trans-Golgi network transport vesicle
copper ion transport
Golgi to plasma membrane transport
integral component of Golgi membrane
iron ion transport
iron ion homeostasis
vesicle-mediated transport to the plasma membrane
post-Golgi vesicle-mediated transport
transition metal ion transport
transition metal ion homeostasis
endosome membrane
early endosome
endosome
Golgi vesicle transport
endocytosis
inorganic cation transmembrane transport
cation transmembrane transport
metal ion homeostasis
metal ion transport
inorganic ion transmembrane transport
import into cell
regulated exocytosis
cation homeostasis
inorganic ion homeostasis
ion homeostasis
exocytosis
cation transport
response to hormone
ion transmembrane transport
oxidation-reduction process
secretion by cell
export from cell
chemical homeostasis
secretion
transmembrane transport
ion transport
response to endogenous stimulus
homeostatic process
vesicle-mediated transport
CRISPR Data
Compound HitMost Correlated Genes in ChemogenomicsTissues where Essential in the Avana Dataset (DepMap 20Q1)