SYCP2
Gene Information
- Official Symbol: SYCP2
- Official Name: synaptonemal complex protein 2
- Aliases and Previous Symbols: N/A
- Entrez ID: 10388
- UniProt: Q9BX26
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: The synaptonemal complex is a proteinaceous structure that links homologous chromosomes during the prophase of meiosis. The protein encoded by this gene is a major component of the synaptonemal complex and may bind DNA at scaffold attachment regions. The encoded protein requires synaptonemal complex protein 3, but not 1, for inclusion in the synaptonemal complex. [provided by RefSeq, Jul 2008].
- UniProt Summary: Major component of the axial/lateral elements of synaptonemal complexes (SCS) during meiotic prophase. Plays a role in the assembly of synaptonemal complexes. Required for normal meiotic chromosome synapsis during oocyte and spermatocyte development and for normal male and female fertility. Required for insertion of SYCP3 into synaptonemal complexes. May be involved in the organization of chromatin by temporarily binding to DNA scaffold attachment regions. Requires SYCP3, but not SYCP1, in order to be incorporated into the axial/lateral elements. {ECO:0000250|UniProtKB:Q9CUU3}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 12811
- Expression level (log2 read counts): 1.25
SYCP2 Expression in NALM6 Cells: 1.25
