TBX2
Gene Information
- Official Symbol: TBX2
- Official Name: T-box transcription factor 2
- Aliases and Previous Symbols: N/A
- Entrez ID: 6909
- UniProt: Q13207
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Involved in the transcriptional regulation of genes required for mesoderm differentiation. Probably plays a role in limb pattern formation. Acts as a negative regulator of PML function in cellular senescence. May be required for cardiac atrioventricular canal formation. {ECO:0000269|PubMed:22002537}.
Pfam Domains GO Terms
Pfam Domains
| TBX |
| T-box |
GO Terms
| regulation of cardiac chamber morphogenesis |
| negative regulation of cardiac chamber morphogenesis |
| regulation of cardiac chamber formation |
| negative regulation of cardiac chamber formation |
| negative regulation of heart looping |
| regulation of heart looping |
| muscle cell fate determination |
| mammary placode formation |
| pharynx development |
| mammary gland formation |
| regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation |
| atrioventricular canal development |
| cardiac muscle cell myoblast differentiation |
| ectodermal placode formation |
| ectodermal placode morphogenesis |
| ectodermal placode development |
| cardioblast differentiation |
| regulation of transcription from RNA polymerase II promoter involved in heart development |
| muscle cell fate commitment |
| negative regulation of morphogenesis of an epithelium |
| positive regulation of cardiac muscle cell proliferation |
| negative regulation of embryonic development |
| embryonic camera-type eye morphogenesis |
| outflow tract septum morphogenesis |
| aorta morphogenesis |
| cellular senescence |
| positive regulation of cardiac muscle tissue growth |
| negative regulation of animal organ morphogenesis |
| embryonic eye morphogenesis |
| myoblast differentiation |
| endocardial cushion morphogenesis |
| positive regulation of heart growth |
| embryonic camera-type eye development |
| cell fate determination |
| regulation of heart morphogenesis |
| regulation of cardiac muscle cell proliferation |
| endocardial cushion development |
| mammary gland morphogenesis |
| positive regulation of cardiac muscle tissue development |
| positive regulation of organ growth |
| mesenchyme morphogenesis |
| aorta development |
| RNA polymerase II activating transcription factor binding |
| regulation of cardiac muscle tissue growth |
| heart looping |
| artery morphogenesis |
| embryonic digit morphogenesis |
| cell aging |
| regulation of heart growth |
| embryonic heart tube morphogenesis |
| determination of heart left/right asymmetry |
| positive regulation of muscle organ development |
| positive regulation of striated muscle tissue development |
| positive regulation of muscle tissue development |
| cardiac septum morphogenesis |
| outflow tract morphogenesis |
| embryonic heart tube development |
| regulation of cardiac muscle tissue development |
| artery development |
| cell fate specification |
| roof of mouth development |
| regulation of organ growth |
| gland morphogenesis |
| cardiac septum development |
| camera-type eye morphogenesis |
| developmental growth involved in morphogenesis |
| cardiocyte differentiation |
| determination of left/right symmetry |
| determination of bilateral symmetry |
| specification of symmetry |
| embryonic limb morphogenesis |
| Notch signaling pathway |
| embryonic appendage morphogenesis |
| cardiac chamber morphogenesis |
| mammary gland development |
| regulation of embryonic development |
| digestive tract development |
| regulation of striated muscle tissue development |
| regulation of muscle tissue development |
| regulation of muscle organ development |
| digestive system development |
| eye morphogenesis |
| appendage morphogenesis |
| limb morphogenesis |
| stem cell differentiation |
| cardiac muscle tissue development |
| cardiac chamber development |
| positive regulation of developmental growth |
| appendage development |
| regulation of morphogenesis of an epithelium |
| limb development |
| transcription factor complex |
| mesenchyme development |
| regulation of heart contraction |
| DNA-binding transcription repressor activity, RNA polymerase II-specific |
| muscle cell differentiation |
| cell fate commitment |
| heart morphogenesis |
| sensory organ morphogenesis |
| regulation of animal organ morphogenesis |
| positive regulation of growth |
| aging |
| striated muscle tissue development |
| regulation of blood circulation |
| embryonic organ morphogenesis |
| muscle tissue development |
| epithelial tube morphogenesis |
| camera-type eye development |
| RNA polymerase II regulatory region sequence-specific DNA binding |
| regulation of developmental growth |
| eye development |
| visual system development |
| sensory system development |
| developmental growth |
| growth |
| blood vessel morphogenesis |
| gland development |
| sequence-specific DNA binding |
| morphogenesis of an epithelium |
| embryonic organ development |
| pattern specification process |
| DNA-binding transcription activator activity, RNA polymerase II-specific |
| muscle structure development |
| blood vessel development |
| RNA polymerase II proximal promoter sequence-specific DNA binding |
| vasculature development |
| cardiovascular system development |
| heart development |
| sensory organ development |
| tissue morphogenesis |
| embryonic morphogenesis |
| regulation of system process |
| tube morphogenesis |
| regulation of growth |
| tube development |
| negative regulation of transcription by RNA polymerase II |
| circulatory system development |
| anatomical structure formation involved in morphogenesis |
| positive regulation of cell population proliferation |
| negative regulation of developmental process |
| animal organ morphogenesis |
| embryo development |
| central nervous system development |
| regulation of anatomical structure morphogenesis |
| epithelium development |
| negative regulation of transcription, DNA-templated |
| negative regulation of multicellular organismal process |
| positive regulation of transcription by RNA polymerase II |
| negative regulation of nucleic acid-templated transcription |
| negative regulation of RNA biosynthetic process |
| negative regulation of RNA metabolic process |
| positive regulation of developmental process |
| negative regulation of cellular macromolecule biosynthetic process |
| negative regulation of nucleobase-containing compound metabolic process |
| DNA binding |
| negative regulation of macromolecule biosynthetic process |
| negative regulation of cellular biosynthetic process |
| positive regulation of transcription, DNA-templated |
| negative regulation of biosynthetic process |
| DNA-binding transcription factor activity, RNA polymerase II-specific |
| regulation of cell population proliferation |
| positive regulation of nucleic acid-templated transcription |
| positive regulation of RNA biosynthetic process |
| cellular response to stress |
| negative regulation of gene expression |
| positive regulation of RNA metabolic process |
| positive regulation of multicellular organismal process |
| tissue development |
| positive regulation of nucleobase-containing compound metabolic process |
| positive regulation of macromolecule biosynthetic process |
| positive regulation of cellular biosynthetic process |
| positive regulation of gene expression |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Atovaquone 15μM R08 exp451 | -1.81 |
| DKK1 89ng/ml R08 exp477 | -1.74 |
| BRD2 inhibitor II 20μM R07 exp341 | -1.7 |
| Nicotinamide 2000μM R01 exp50 | 1.74 |
| Taxol 0.002μM R01 exp54 | 2.32 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 3/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 1/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 1/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 7265
- Expression level (log2 read counts): 0.84
Expression Distribution
TBX2 Expression in NALM6 Cells: 0.84
