Entrez Summary: There are several documented fusion oncoproteins encoded partially by this gene. This gene also participates in several oncogenic rearrangements resulting in anaplastic lymphoma and mixoid chondrosarcoma, and may play a role in the NF-kappaB pathway. Multiple transcript variants have been found for this gene. [provided by RefSeq, Sep 2010].
UniProt Summary: Plays a role in the normal dynamic function of the endoplasmic reticulum (ER) and its associated microtubules (PubMed:23479643, PubMed:27813252). {ECO:0000269|PubMed:23479643, ECO:0000269|PubMed:27813252}.
Pfam DomainsGO Terms
Pfam Domains
PB1
GO Terms
endoplasmic reticulum exit site
COPII vesicle coating
vesicle targeting, rough ER to cis-Golgi
vesicle coating
COPII-coated vesicle budding
vesicle targeting, to, from or within Golgi
Golgi vesicle budding
vesicle targeting
vesicle budding from membrane
establishment of vesicle localization
positive regulation of I-kappaB kinase/NF-kappaB signaling
vesicle localization
endoplasmic reticulum to Golgi vesicle-mediated transport
regulation of I-kappaB kinase/NF-kappaB signaling
vesicle organization
establishment of organelle localization
Golgi vesicle transport
organelle localization
Golgi membrane
membrane organization
positive regulation of intracellular signal transduction
identical protein binding
intracellular transport
protein-containing complex assembly
positive regulation of signal transduction
positive regulation of cell communication
positive regulation of signaling
regulation of intracellular signal transduction
establishment of localization in cell
protein-containing complex subunit organization
vesicle-mediated transport
CRISPR Data
Compound HitMost Correlated Genes in ChemogenomicsTissues where Essential in the Avana Dataset (DepMap 20Q1)