TIFAB
Gene Information
- Official Symbol: TIFAB
- Official Name: TIFA inhibitor
- Aliases and Previous Symbols: N/A
- Entrez ID: 497189
- UniProt: Q6ZNK6
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Inhibits TIFA-mediated TRAF6 activation possibly by inducing a conformational change in TIFA. {ECO:0000269|PubMed:15047173}.
Pfam Domains GO Terms
Pfam Domains
| FHA |
GO Terms
| learned vocalization behavior |
| mastication |
| negative regulation of saliva secretion |
| hard palate morphogenesis |
| vestibulocochlear nerve formation |
| negative regulation of relaxation of muscle |
| thorax and anterior abdomen determination |
| zygotic determination of anterior/posterior axis, embryo |
| regulation of saliva secretion |
| vestibulocochlear nerve morphogenesis |
| cranial nerve formation |
| learned vocalization behavior or vocal learning |
| vestibulocochlear nerve development |
| peristalsis |
| regulation of relaxation of muscle |
| trigeminal nerve development |
| auditory behavior |
| genitalia morphogenesis |
| mechanosensory behavior |
| anterior/posterior axis specification, embryo |
| tripartite regional subdivision |
| craniofacial suture morphogenesis |
| vocalization behavior |
| phasic smooth muscle contraction |
| blastoderm segmentation |
| negative regulation of digestive system process |
| cochlea morphogenesis |
| response to auditory stimulus |
| cranial nerve morphogenesis |
| embryonic axis specification |
| regulation of digestive system process |
| genitalia development |
| anterior/posterior axis specification |
| cochlea development |
| cranial nerve development |
| smooth muscle contraction |
| neuromuscular process controlling balance |
| embryonic pattern specification |
| cranial skeletal system development |
| I-kappaB kinase/NF-kappaB signaling |
| digestive system process |
| nerve development |
| axis specification |
| segmentation |
| inner ear morphogenesis |
| neuromuscular process |
| digestion |
| bone morphogenesis |
| ear morphogenesis |
| regulation of muscle organ development |
| inner ear development |
| bone development |
| response to mechanical stimulus |
| anterior/posterior pattern specification |
| ear development |
| negative regulation of secretion |
| regulation of muscle system process |
| skeletal system morphogenesis |
| muscle contraction |
| sensory organ morphogenesis |
| learning or memory |
| sex differentiation |
| embryonic organ morphogenesis |
| cognition |
| muscle system process |
| regionalization |
| reproductive structure development |
| reproductive system development |
| embryonic organ development |
| pattern specification process |
| negative regulation of transport |
| skeletal system development |
| regulation of body fluid levels |
| sensory organ development |
| embryonic morphogenesis |
| behavior |
| regulation of system process |
| developmental process involved in reproduction |
| regulation of secretion |
| anatomical structure formation involved in morphogenesis |
| animal organ morphogenesis |
| embryo development |
| response to abiotic stimulus |
| negative regulation of multicellular organismal process |
| nervous system process |
| reproductive process |
| reproduction |
| intracellular signal transduction |
| regulation of transport |
| system process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| ETC-159 50μM R08 exp480 | -1.92 |
| RO-3306 3 to 4μM on day4 R04 exp165 | 1.7 |
| Fas-L 44ng/ml R08 exp482 | 1.78 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 3440
- Expression level (log2 read counts): -6.6
Expression Distribution
TIFAB Expression in NALM6 Cells: -6.6
