TMEM127

Entrez Summary: This gene encodes a transmembrane protein with 3 predicted transmembrane domains. The protein is associated with a subpopulation of vesicular organelles corresponding to early endosomal structures, with the Golgi, and with lysosomes, and may participate in protein trafficking between these structures. Mutations in this gene and several other genes cause pheochromocytomas. Alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Aug 2010].
UniProt Summary: Controls cell proliferation acting as a negative regulator of TOR signaling pathway mediated by mTORC1. May act as a tumor suppressor. {ECO:0000269|PubMed:20154675}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Vincristine 0.0005μM R04 exp190	-2.92
THZ531 0.225μM R08 exp444	-2.9
MLN-4924 0.2μM R00 exp21	-2.68
Docetaxel 0.002μM R01 exp45	-2.01
THZ1 0.06μM R08 exp531	-1.86
UM0125461 0.74μM R02 exp84	-1.82
Trientine 500μM R08 exp534	-1.78
Rotenone 20μM R00 exp34	-1.77
THZ531 0.11 to 0.125 to 0.35μM on day4 then day6 R07 exp412	-1.76
Vemurafenib 6.6μM R02 exp89	1.77
Q15 2.7μM R02 exp79	1.81
Vemurafenib 6.6μM R08 exp434	2.29

Global Fraction of Cell Lines Where Essential: 3/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	1/15
prostate	0/1
skin	1/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution