TPT1
Gene Information
- Official Symbol: TPT1
- Official Name: tumor protein, translationally-controlled 1
- Aliases and Previous Symbols: N/A
- Entrez ID: 7178
- UniProt: P13693
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Involved in calcium binding and microtubule stabilization.
Pfam Domains GO Terms
Pfam Domains
| TCTP |
GO Terms
| negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage |
| multivesicular body |
| regulation of intrinsic apoptotic signaling pathway in response to DNA damage |
| cytoplasmic microtubule |
| negative regulation of response to DNA damage stimulus |
| negative regulation of intrinsic apoptotic signaling pathway |
| spindle pole |
| regulation of intrinsic apoptotic signaling pathway |
| regulation of response to DNA damage stimulus |
| negative regulation of apoptotic signaling pathway |
| calcium ion transport |
| response to virus |
| divalent metal ion transport |
| divalent inorganic cation transport |
| regulation of apoptotic signaling pathway |
| cellular calcium ion homeostasis |
| calcium ion homeostasis |
| cellular divalent inorganic cation homeostasis |
| divalent inorganic cation homeostasis |
| negative regulation of intracellular signal transduction |
| cellular metal ion homeostasis |
| metal ion homeostasis |
| cellular cation homeostasis |
| metal ion transport |
| cellular ion homeostasis |
| cation homeostasis |
| inorganic ion homeostasis |
| calcium ion binding |
| regulation of cellular response to stress |
| cellular chemical homeostasis |
| ion homeostasis |
| cation transport |
| negative regulation of apoptotic process |
| cellular homeostasis |
| negative regulation of programmed cell death |
| negative regulation of cell death |
| chemical homeostasis |
| negative regulation of signal transduction |
| response to other organism |
| response to external biotic stimulus |
| response to biotic stimulus |
| negative regulation of cell communication |
| negative regulation of signaling |
| ion transport |
| RNA binding |
| regulation of response to stress |
| regulation of apoptotic process |
| regulation of programmed cell death |
| extracellular space |
| negative regulation of response to stimulus |
| homeostatic process |
| regulation of cell death |
| regulation of intracellular signal transduction |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
Most Correlated Genes in Chemogenomics
| Gene | Correlation |
|---|---|
| DPH6 | 0.428 |
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 210/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 4/28 |
| blood | 10/28 |
| bone | 9/26 |
| breast | 8/33 |
| central nervous system | 16/56 |
| cervix | 2/4 |
| colorectal | 7/17 |
| esophagus | 4/13 |
| fibroblast | 1/1 |
| gastric | 3/16 |
| kidney | 9/21 |
| liver | 9/20 |
| lung | 20/75 |
| lymphocyte | 3/16 |
| ovary | 6/26 |
| pancreas | 6/24 |
| peripheral nervous system | 4/16 |
| plasma cell | 9/15 |
| prostate | 1/1 |
| skin | 8/24 |
| soft tissue | 3/9 |
| thyroid | 1/2 |
| upper aerodigestive | 5/22 |
| urinary tract | 6/29 |
| uterus | 1/5 |
Essentiality in NALM6
- Essentiality Rank: 1223
- Expression level (log2 read counts): 9.82
Expression Distribution
TPT1 Expression in NALM6 Cells: 9.82
