TRMT1
Gene Information
- Official Symbol: TRMT1
- Official Name: tRNA methyltransferase 1
- Aliases and Previous Symbols: N/A
- Entrez ID: 55621
- UniProt: Q9NXH9
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene encodes a tRNA-modifying enzyme that acts as a dimethyltransferase, modifying a single guanine residue at position 26 of the tRNA. The encoded enzyme has both mono- and dimethylase activity when exogenously expressed, and uses S-adenosyl methionine as a methyl donor. The C-terminal region of the encoded protein has both a zinc finger motif, and an arginine/proline-rich region. Mutations in this gene have been implicated in autosomal recessive intellectual disorder (ARID). Alternative splicing results in multiple transcript variants encoding different isoforms. There is a pseudogene of this gene on the X chromosome. [provided by RefSeq, May 2017].
- UniProt Summary: Dimethylates a single guanine residue at position 26 of most tRNAs using S-adenosyl-L-methionine as donor of the methyl groups.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 3362
- Expression level (log2 read counts): 6.26
TRMT1 Expression in NALM6 Cells: 6.26
