TTF2

Entrez Summary: N/A
UniProt Summary: DsDNA-dependent ATPase which acts as a transcription termination factor by coupling ATP hydrolysis with removal of RNA polymerase II from the DNA template. May contribute to mitotic transcription repression. May also be involved in pre-mRNA splicing. {ECO:0000269|PubMed:10455150, ECO:0000269|PubMed:12927788, ECO:0000269|PubMed:15125840, ECO:0000269|PubMed:9748214}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 117/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	2/28
blood	6/28
bone	6/25
breast	3/33
central nervous system	4/56
cervix	0/4
colorectal	5/17
esophagus	3/13
fibroblast	0/1
gastric	3/15
kidney	5/21
liver	4/20
lung	17/75
lymphocyte	3/14
ovary	3/26
pancreas	4/24
peripheral nervous system	2/16
plasma cell	4/15
prostate	0/1
skin	5/24
soft tissue	1/7
thyroid	0/2
upper aerodigestive	3/22
urinary tract	6/29
uterus	1/5

Expression Distribution