Pfam Domains GO Terms
| Thioredoxin |
| negative regulation of protein export from nucleus |
| thioredoxin-disulfide reductase activity |
| peptide disulfide oxidoreductase activity |
| glycerol ether metabolic process |
| negative regulation of hydrogen peroxide-induced cell death |
| negative regulation of response to reactive oxygen species |
| ether metabolic process |
| negative regulation of nucleocytoplasmic transport |
| negative regulation of cellular response to drug |
| maintenance of protein location in nucleus |
| regulation of hydrogen peroxide-induced cell death |
| protein disulfide oxidoreductase activity |
| negative regulation of response to drug |
| activation of protein kinase B activity |
| regulation of response to reactive oxygen species |
| regulation of cellular response to drug |
| regulation of protein export from nucleus |
| maintenance of protein localization in organelle |
| negative regulation of intracellular protein transport |
| negative regulation of oxidative stress-induced cell death |
| negative regulation of cellular response to oxidative stress |
| negative regulation of response to oxidative stress |
| positive regulation of DNA binding |
| negative regulation of intracellular transport |
| regulation of oxidative stress-induced cell death |
| regulation of cellular response to oxidative stress |
| maintenance of protein location in cell |
| cell redox homeostasis |
| regulation of response to oxidative stress |
| cellular oxidant detoxification |
| maintenance of location in cell |
| regulation of response to drug |
| cellular detoxification |
| positive regulation of peptidyl-serine phosphorylation |
| maintenance of protein location |
| regulation of nucleocytoplasmic transport |
| negative regulation of cellular protein localization |
| regulation of DNA binding |
| detoxification |
| regulation of peptidyl-serine phosphorylation |
| protein localization to nucleus |
| maintenance of location |
| positive regulation of protein kinase B signaling |
| positive regulation of binding |
| negative regulation of protein transport |
| negative regulation of establishment of protein localization |
| cellular response to toxic substance |
| regulation of protein kinase B signaling |
| regulation of intracellular protein transport |
| activation of protein kinase activity |
| regulation of intracellular transport |
| regulation of binding |
| response to radiation |
| negative regulation of transport |
| response to toxic substance |
| positive regulation of protein kinase activity |
| regulation of cellular protein localization |
| positive regulation of kinase activity |
| positive regulation of transferase activity |
| regulation of protein transport |
| protein localization to organelle |
| regulation of cellular response to stress |
| regulation of peptide transport |
| regulation of establishment of protein localization |
| regulation of protein kinase activity |
| negative regulation of transcription by RNA polymerase II |
| regulation of kinase activity |
| cellular homeostasis |
| regulation of cellular localization |
| oxidation-reduction process |
| regulation of transferase activity |
| negative regulation of cell death |
| positive regulation of protein phosphorylation |
| positive regulation of intracellular signal transduction |
| regulation of protein localization |
| positive regulation of phosphorylation |
| positive regulation of phosphorus metabolic process |
| positive regulation of phosphate metabolic process |
| response to abiotic stimulus |
| negative regulation of transcription, DNA-templated |
| positive regulation of protein modification process |
| negative regulation of nucleic acid-templated transcription |
| negative regulation of RNA biosynthetic process |
| negative regulation of RNA metabolic process |
| negative regulation of cellular macromolecule biosynthetic process |
| RNA binding |
| positive regulation of catalytic activity |
| negative regulation of nucleobase-containing compound metabolic process |
| regulation of protein phosphorylation |
| negative regulation of macromolecule biosynthetic process |
| regulation of response to stress |
| negative regulation of cellular biosynthetic process |
| negative regulation of biosynthetic process |
| cellular protein localization |
| regulation of phosphorylation |
| cellular macromolecule localization |
| positive regulation of cellular protein metabolic process |
| negative regulation of response to stimulus |
| homeostatic process |
| positive regulation of signal transduction |
| regulation of cell death |
| positive regulation of protein metabolic process |
| negative regulation of gene expression |
| small molecule metabolic process |
| positive regulation of molecular function |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| positive regulation of cell communication |
| positive regulation of signaling |
| regulation of intracellular signal transduction |
| regulation of protein modification process |
| regulation of transport |
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
| Screen | Score |
|---|---|
| Thimerosal 0.85μM R08 exp529 | -2.08 |
| S-trityl-L-cysteine 0.5μM R05 exp243 | -1.89 |
| Deguelin 0.05μM R02 exp69 | 1.85 |
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 1/1 |
| 909776.0 | 1/1 |
| bile duct | 26/28 |
| blood | 28/28 |
| bone | 25/26 |
| breast | 31/33 |
| central nervous system | 54/56 |
| cervix | 4/4 |
| colorectal | 16/17 |
| esophagus | 12/13 |
| fibroblast | 1/1 |
| gastric | 16/16 |
| kidney | 20/21 |
| liver | 19/20 |
| lung | 74/75 |
| lymphocyte | 15/16 |
| ovary | 24/26 |
| pancreas | 24/24 |
| peripheral nervous system | 16/16 |
| plasma cell | 14/15 |
| prostate | 1/1 |
| skin | 24/24 |
| soft tissue | 9/9 |
| thyroid | 2/2 |
| upper aerodigestive | 19/22 |
| urinary tract | 28/29 |
| uterus | 5/5 |
Expression Distribution