VPS37B

Entrez Summary: N/A
UniProt Summary: Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation. {ECO:0000269|PubMed:15218037}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
GSK461364A 0.1μM R03 exp126	-2.2
Asunaprenir 3μM R07 exp336	-1.98
FK-506 30μM R07 exp359	-1.91
DABN racemic mixture R03 exp93	-1.78
BI-6727 0.04μM R03 exp98	-1.76
Oligomycin-A 20μM R00 exp26	-1.71
Mitomycin-C 0.06μM R08 exp503	1.71
UM131593 0.1μM R01 exp58	1.78
Nocodazole 0.02μM R00 exp23	1.98
Lead acetate 2000μM R08 exp497	2.45
Nifuroxazide 1μM R01 exp51	2.91
Lead acetate 2000μM R08 exp498 no dilution day6	3.42

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution