XPO4
Gene Information
- Official Symbol: XPO4
- Official Name: exportin 4
- Aliases and Previous Symbols: N/A
- Entrez ID: 64328
- UniProt: Q9C0E2
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Mediates the nuclear export of proteins (cargos) with broad substrate specificity. In the nucleus binds cooperatively to its cargo and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the cargo from the export receptor. XPO4 then return to the nuclear compartment and mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. {ECO:0000269|PubMed:10944119, ECO:0000269|PubMed:16449645}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 1817
- Expression level (log2 read counts): 7.35
XPO4 Expression in NALM6 Cells: 7.35
