ABLIM3

Entrez Summary: This gene encodes a member of the actin-binding LIM (abLIM) family of proteins. These proteins are characterized by an N-terminal LIM domain and a C-terminal dematin-like domain. The encoded protein interacts with actin filaments and may be a component of adherens junctions in several cell types. A variant of this gene may be associated with pain sensitivity in male human patients. [provided by RefSeq, Sep 2016].
UniProt Summary: May act as scaffold protein. May stimulate ABRA activity and ABRA-dependent SRF transcriptional activity. {ECO:0000269|PubMed:17194709}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
JQ1 0.01μM R03 exp130	-2.09
Hippuristanol 0.12μM R08 exp489 no dilution day6	1.83

LIM
VHP

positive regulation of protein targeting to mitochondrion
lamellipodium assembly
lamellipodium organization
regulation of protein targeting to mitochondrion
positive regulation of establishment of protein localization to mitochondrion
stress fiber
regulation of establishment of protein localization to mitochondrion
regulation of protein targeting
positive regulation of mitochondrion organization
positive regulation of intracellular protein transport
lamellipodium
regulation of mitochondrion organization
actin filament binding
positive regulation of intracellular transport
actin cytoskeleton
regulation of intracellular protein transport
positive regulation of cellular protein localization
cilium assembly
glutamatergic synapse
regulation of intracellular transport
cilium organization
positive regulation of protein transport
plasma membrane bounded cell projection assembly
cell projection assembly
positive regulation of establishment of protein localization
actin cytoskeleton organization
regulation of cellular protein localization
actin filament-based process
positive regulation of organelle organization
transcription, DNA-templated
nucleic acid-templated transcription
RNA biosynthetic process
regulation of protein transport
regulation of peptide transport
regulation of establishment of protein localization
organelle assembly
regulation of cellular localization
positive regulation of transport
regulation of protein localization
nucleobase-containing compound biosynthetic process