ALDH8A1

Entrez Summary: This protein belongs to the aldehyde dehydrogenases family of proteins. It plays a role in a pathway of 9-cis-retinoic acid biosynthesis in vivo. This enzyme converts 9-cis-retinal into the retinoid X receptor ligand 9-cis-retinoic acid, and has approximately 40-fold higher activity with 9-cis-retinal than with all-trans-retinal. Therefore, it is the first known aldehyde dehydrogenase to show a preference for 9-cis-retinal relative to all-trans-retinal. Three transcript variants encoding distinct protein isoforms have been identified for this gene. [provided by RefSeq, Jul 2010].
UniProt Summary: Converts 9-cis-retinal to 9-cis-retinoic acid. Has lower activity towards 13-cis-retinal. Has much lower activity towards all-trans-retinal. Has highest activity with benzaldehyde and decanal (in vitro). Has a preference for NAD, but shows considerable activity with NADP (in vitro). {ECO:0000269|PubMed:11007799}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

aminomuconate-semialdehyde dehydrogenase activity
L-kynurenine catabolic process
9-cis-retinoic acid biosynthetic process
9-cis-retinoic acid metabolic process
L-kynurenine metabolic process
retinoic acid biosynthetic process
retinal dehydrogenase activity
diterpenoid biosynthetic process
ketone catabolic process
kynurenine metabolic process
retinal metabolic process
terpenoid biosynthetic process
benzene-containing compound metabolic process
isoprenoid biosynthetic process
retinoic acid metabolic process
cellular aldehyde metabolic process
cellular ketone metabolic process
retinoid metabolic process
alpha-amino acid catabolic process
diterpenoid metabolic process
terpenoid metabolic process
cellular hormone metabolic process
cellular amino acid catabolic process
isoprenoid metabolic process
monocarboxylic acid biosynthetic process
hormone metabolic process
alpha-amino acid metabolic process
carboxylic acid catabolic process
organic acid catabolic process
carboxylic acid biosynthetic process
organic acid biosynthetic process
cellular amino acid metabolic process
small molecule catabolic process
aromatic compound catabolic process
organic cyclic compound catabolic process
drug metabolic process
monocarboxylic acid metabolic process
regulation of hormone levels
lipid biosynthetic process
small molecule biosynthetic process