AOC3

Entrez Summary: N/A
UniProt Summary: Cell adhesion protein that participates in lymphocyte extravasation and recirculation by mediating the binding of lymphocytes to peripheral lymph node vascular endothelial cells in an L-selectin-independent fashion. Has semicarbazide-sensitive (SSAO) monoamine oxidase activity. May play a role in adipogenesis. {ECO:0000269|PubMed:17400359, ECO:0000269|PubMed:19588076, ECO:0000269|PubMed:23349812, ECO:0000269|PubMed:9653080}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

aliphatic-amine oxidase activity
tryptamine:oxygen oxidoreductase (deaminating) activity
phenethylamine:oxygen oxidoreductase (deaminating) activity
negative regulation of primary amine oxidase activity
aminoacetone:oxygen oxidoreductase(deaminating) activity
primary amine oxidase activity
quinone binding
negative regulation of oxidoreductase activity
copper ion binding
microvillus
amine metabolic process
regulation of oxidoreductase activity
xenobiotic metabolic process
cellular response to xenobiotic stimulus
early endosome
response to xenobiotic stimulus
response to antibiotic
protein heterodimerization activity
inflammatory response
cell surface
calcium ion binding
negative regulation of catalytic activity
protein homodimerization activity
cell adhesion
biological adhesion
oxidation-reduction process
Golgi apparatus
endoplasmic reticulum
negative regulation of molecular function
defense response