ARF6
Gene Information
- Official Symbol: ARF6
- Official Name: ADP ribosylation factor 6
- Aliases and Previous Symbols: N/A
- Entrez ID: 382
- UniProt: P62330
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: GTP-binding protein involved in protein trafficking that regulates endocytic recycling and cytoskeleton remodeling. Required for normal completion of mitotic cytokinesis. Plays a role in the reorganization of the actin cytoskeleton and the formation of stress fibers. May also modulate vesicle budding and uncoating within the Golgi apparatus. Involved in the regulation of dendritic spine development, contributing to the regulation of dendritic branching and filopodia extension. Involved in epithelial polarization (By similarity).Functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP- ribosyltransferase. {ECO:0000250|UniProtKB:P62330, ECO:0000269|PubMed:11266366, ECO:0000269|PubMed:14978216, ECO:0000269|PubMed:16099990, ECO:0000269|PubMed:16737952, ECO:0000269|PubMed:18400762, ECO:0000269|PubMed:21170023, ECO:0000269|PubMed:7589240}.
Pfam Domains GO Terms
Pfam Domains
| SRPRB |
| Arf |
| Miro |
| G-alpha |
| Gtr1 RagA |
| Ras |
GO Terms
| maintenance of postsynaptic density structure |
| myeloid cell apoptotic process |
| maintenance of postsynaptic specialization structure |
| hepatocyte apoptotic process |
| thioesterase binding |
| positive regulation of protein homodimerization activity |
| protein localization to endosome |
| positive regulation of keratinocyte migration |
| ruffle assembly |
| negative regulation of protein localization to cell surface |
| regulation of keratinocyte migration |
| regulation of Rac protein signal transduction |
| maintenance of synapse structure |
| postsynaptic density organization |
| postsynaptic specialization organization |
| filopodium membrane |
| regulation of protein homodimerization activity |
| negative regulation of receptor-mediated endocytosis |
| ruffle organization |
| protein localization to cell surface |
| epithelial cell apoptotic process |
| Flemming body |
| negative regulation of dendrite development |
| regulation of presynapse assembly |
| regulation of presynapse organization |
| establishment of epithelial cell polarity |
| positive regulation of adherens junction organization |
| endocytic recycling |
| regulation of protein localization to cell surface |
| cortical actin cytoskeleton organization |
| negative regulation of endocytosis |
| synaptic vesicle endocytosis |
| presynaptic endocytosis |
| regulation of filopodium assembly |
| cellular component maintenance |
| cortical cytoskeleton organization |
| cellular response to nerve growth factor stimulus |
| synaptic vesicle recycling |
| response to nerve growth factor |
| cleavage furrow |
| positive regulation of protein localization to plasma membrane |
| endocytic vesicle |
| positive regulation of protein localization to cell periphery |
| regulation of adherens junction organization |
| regulation of dendritic spine development |
| recycling endosome membrane |
| postsynapse organization |
| positive regulation of actin filament polymerization |
| ruffle |
| positive regulation of protein binding |
| regulation of protein localization to plasma membrane |
| presynapse |
| regulation of receptor-mediated endocytosis |
| regulation of synapse assembly |
| protein N-terminus binding |
| negative regulation of cellular protein localization |
| regulation of protein localization to cell periphery |
| establishment of cell polarity |
| synaptic vesicle cycle |
| positive regulation of protein localization to membrane |
| liver development |
| positive regulation of protein polymerization |
| hepaticobiliary system development |
| vesicle-mediated transport in synapse |
| cell cortex |
| positive regulation of epithelial cell migration |
| regulation of dendrite development |
| early endosome membrane |
| negative regulation of neuron projection development |
| regulation of actin filament polymerization |
| positive regulation of binding |
| negative regulation of cell projection organization |
| regulation of actin polymerization or depolymerization |
| regulation of actin filament length |
| regulation of protein localization to membrane |
| establishment or maintenance of cell polarity |
| positive regulation of supramolecular fiber organization |
| regulation of plasma membrane bounded cell projection assembly |
| regulation of cell projection assembly |
| regulation of endocytosis |
| regulation of synapse organization |
| regulation of protein binding |
| regulation of epithelial cell migration |
| positive regulation of cytoskeleton organization |
| regulation of protein polymerization |
| negative regulation of neuron differentiation |
| regulation of synapse structure or activity |
| endosomal transport |
| regulation of Ras protein signal transduction |
| positive regulation of protein complex assembly |
| regulation of actin filament organization |
| synapse organization |
| positive regulation of protein secretion |
| endosome |
| positive regulation of peptide secretion |
| negative regulation of neurogenesis |
| negative regulation of nervous system development |
| positive regulation of cellular protein localization |
| GTPase activity |
| negative regulation of cell development |
| regulation of actin cytoskeleton organization |
| regulation of small GTPase mediated signal transduction |
| glutamatergic synapse |
| regulation of supramolecular fiber organization |
| regulation of binding |
| regulation of cellular component size |
| regulation of actin filament-based process |
| GTP binding |
| positive regulation of secretion by cell |
| gland development |
| focal adhesion |
| positive regulation of protein transport |
| positive regulation of secretion |
| plasma membrane bounded cell projection assembly |
| regulation of protein complex assembly |
| cell projection assembly |
| positive regulation of establishment of protein localization |
| regulation of protein secretion |
| negative regulation of transport |
| cell division |
| actin cytoskeleton organization |
| regulation of peptide secretion |
| regulation of neuron projection development |
| cellular response to growth factor stimulus |
| positive regulation of cell migration |
| regulation of anatomical structure size |
| positive regulation of cellular component biogenesis |
| positive regulation of cell motility |
| response to growth factor |
| positive regulation of cellular component movement |
| regulation of cellular protein localization |
| regulation of cytoskeleton organization |
| regulation of vesicle-mediated transport |
| positive regulation of locomotion |
| endocytosis |
| actin filament-based process |
| positive regulation of organelle organization |
| regulation of neuron differentiation |
| import into cell |
| regulation of plasma membrane bounded cell projection organization |
| negative regulation of cellular component organization |
| regulation of protein transport |
| regulation of cell projection organization |
| negative regulation of cell differentiation |
| protein localization to organelle |
| regulation of peptide transport |
| regulation of establishment of protein localization |
| regulation of secretion by cell |
| regulation of secretion |
| regulation of neurogenesis |
| regulation of cell migration |
| regulation of cell motility |
| regulation of cellular localization |
| apoptotic process |
| regulation of nervous system development |
| cell adhesion |
| regulation of cell development |
| biological adhesion |
| negative regulation of developmental process |
| regulation of cellular component biogenesis |
| regulation of locomotion |
| Golgi apparatus |
| positive regulation of transport |
| intracellular protein transport |
| regulation of cellular component movement |
| regulation of protein localization |
| programmed cell death |
| cell death |
| cytoskeleton organization |
| plasma membrane bounded cell projection organization |
| cell projection organization |
| negative regulation of multicellular organismal process |
| positive regulation of cellular component organization |
| cellular response to endogenous stimulus |
| regulation of organelle organization |
| cell cycle |
| response to endogenous stimulus |
| protein transport |
| intracellular transport |
| generation of neurons |
| peptide transport |
| amide transport |
| cellular protein localization |
| cellular macromolecule localization |
| establishment of protein localization |
| neurogenesis |
| positive regulation of multicellular organismal process |
| positive regulation of molecular function |
| regulation of cell differentiation |
| regulation of intracellular signal transduction |
| establishment of localization in cell |
| nitrogen compound transport |
| regulation of transport |
| vesicle-mediated transport |
| membrane |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 9/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 1/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 1/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 1/75 |
| lymphocyte | 1/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 1/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 14256
- Expression level (log2 read counts): 6.7
Expression Distribution
ARF6 Expression in NALM6 Cells: 6.7
