ASCC3

Entrez Summary: N/A
UniProt Summary: 3'-5' DNA helicase involved in repair of alkylated DNA. Promotes DNA unwinding to generate single-stranded substrate needed for ALKBH3, enabling ALKBH3 to process alkylated N3- methylcytosine (3mC) within double-stranded regions. Enhances NF- kappa-B, SRF and AP1 transactivation. {ECO:0000269|PubMed:22055184}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

activating signal cointegrator 1 complex
DNA dealkylation involved in DNA repair
3-5 DNA helicase activity
DNA dealkylation
helicase activity
intracellular
DNA modification
DNA duplex unwinding
DNA geometric change
DNA conformation change
nuclear speck
DNA repair
cell population proliferation
DNA metabolic process
cellular response to DNA damage stimulus
chromosome organization
RNA binding
ATP binding
cellular response to stress
membrane