BAIAP2L1

Gene Information

Official Symbol: BAIAP2L1
Official Name: BAR/IMD domain containing adaptor protein 2 like 1
Aliases and Previous Symbols: N/A
Entrez ID: 55971
UniProt: Q9UHR4
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene encodes a member of the IMD (IRSp53/MIM homology domain) family. Members of this family can be subdivided in two groups, the IRSp53-like and MIM-like, based on the presence or absence of the SH3 (Src homology 3) domain. The protein encoded by this gene contains a conserved IMD, also known as F-actin bundling domain, at the N-terminus, and a canonical SH3 domain near the C-terminus, so it belongs to the IRSp53-like group. This protein is the substrate for insulin receptor tyrosine kinase and binds to the small GTPase Rac. It is involved in signal transduction pathways that link deformation of the plasma membrane and remodeling of the actin cytoskeleton. It also promotes actin assembly and membrane protrusions when overexpressed in mammalian cells, and is essential to the formation of a potent actin assembly complex during EHEC (Enterohemorrhagic Escherichia coli) pedestal formation. [provided by RefSeq, Oct 2009].
UniProt Summary: May function as adapter protein. Involved in the formation of clusters of actin bundles. Plays a role in the reorganization of the actin cytoskeleton in response to bacterial infection. {ECO:0000269|PubMed:17430976, ECO:0000269|PubMed:19366662, ECO:0000269|PubMed:22921828}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 12540
Expression level (log2 read counts): 0.43

Expression Distribution

Screen	Score
Mubritinib 0.2μM R02 exp65	-1.86
CFI-400945 25μM R08 exp469	-1.73
Vitamin-D3 40μM R08 exp536	-1.72
Metformin 100 to 150μM on day4 R04 exp170	1.72

IMD
SH3 2

actin crosslink formation
proline-rich region binding
cadherin binding involved in cell-cell adhesion
positive regulation of actin cytoskeleton reorganization
regulation of actin cytoskeleton reorganization
actin filament bundle assembly
regulation of insulin receptor signaling pathway
actin filament bundle organization
regulation of cellular response to insulin stimulus
positive regulation of actin filament polymerization
plasma membrane organization
cell-cell adherens junction
positive regulation of protein polymerization
regulation of actin filament polymerization
regulation of actin polymerization or depolymerization
regulation of actin filament length
positive regulation of supramolecular fiber organization
actin cytoskeleton
positive regulation of cytoskeleton organization
regulation of protein polymerization
actin filament organization
positive regulation of protein complex assembly
regulation of actin filament organization
actin binding
regulation of actin cytoskeleton organization
regulation of supramolecular fiber organization
regulation of cellular component size
regulation of actin filament-based process
endomembrane system organization
regulation of protein complex assembly
supramolecular fiber organization
actin cytoskeleton organization
cell-cell adhesion
regulation of anatomical structure size
positive regulation of cellular component biogenesis
regulation of cytoskeleton organization
actin filament-based process
positive regulation of organelle organization
response to bacterium
membrane organization