CAPZA2

Gene Information

Official Symbol: CAPZA2
Official Name: capping actin protein of muscle Z-line subunit alpha 2
Aliases and Previous Symbols: N/A
Entrez ID: 830
UniProt: P47755
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 4733
Expression level (log2 read counts): 5.42

Expression Distribution

Screen	Score
Ibrutinib 1μM R07 exp372	-2.14
5-Fluorouracil 2μM R00 exp1	-1.8
2-Deoxy-D-glucose 800μM R05 exp214	1.73
SGC2043 10μM R03 exp152	2.54

F-actin capping protein complex
barbed-end actin filament capping
actin cortical patch
actin filament capping
negative regulation of actin filament depolymerization
regulation of actin filament depolymerization
brush border
negative regulation of actin filament polymerization
negative regulation of protein depolymerization
negative regulation of protein polymerization
negative regulation of protein complex disassembly
regulation of protein depolymerization
antigen processing and presentation of exogenous peptide antigen via MHC class II
antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
antigen processing and presentation of peptide antigen via MHC class II
regulation of protein complex disassembly
negative regulation of supramolecular fiber organization
negative regulation of protein complex assembly
negative regulation of cytoskeleton organization
regulation of actin filament polymerization
antigen processing and presentation of exogenous peptide antigen
regulation of actin polymerization or depolymerization
regulation of actin filament length
antigen processing and presentation of exogenous antigen
antigen processing and presentation of peptide antigen
actin filament binding
endoplasmic reticulum to Golgi vesicle-mediated transport
actin cytoskeleton
antigen processing and presentation
regulation of protein polymerization
regulation of actin filament organization
blood coagulation
coagulation
hemostasis
regulation of actin cytoskeleton organization
regulation of supramolecular fiber organization
Golgi vesicle transport
negative regulation of organelle organization
regulation of cellular component size
regulation of actin filament-based process