CDC26

Entrez Summary: N/A
UniProt Summary: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. May recruit the E2 ubiquitin-conjugating enzymes to the complex. {ECO:0000269|PubMed:18485873}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Mubritinib 0.2μM R01 exp48	-2.2
ABT-702 0.1μM R06 exp260	-2.17
BVD-523 15μM R02 exp67	-2.05
Phorbol-12-myristate-13-acetate 0.57μM R08 exp514	-1.88
CFI-400945 25μM R08 exp469	-1.84
Vinblastine 0.002μM R01 exp60	-1.84
FK-506 5μM R07 exp358	-1.83
Q15 2.7μM R02 exp79	-1.83
Cryptotanshinone 12μM R05 exp227	-1.82
GSK-J4 1.5μM R08 exp441	-1.73
Ixabepilone 0.004 to 0.005μM on day4 R04 exp184	2.01

Global Fraction of Cell Lines Where Essential: 20/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	1/28
blood	1/28
bone	1/26
breast	2/33
central nervous system	1/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	2/16
kidney	1/21
liver	0/20
lung	2/75
lymphocyte	0/16
ovary	1/26
pancreas	0/24
peripheral nervous system	1/16
plasma cell	0/15
prostate	0/1
skin	1/24
soft tissue	1/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

anaphase-promoting complex
protein K11-linked ubiquitination
regulation of mitotic metaphase/anaphase transition
regulation of metaphase/anaphase transition of cell cycle
regulation of mitotic sister chromatid separation
regulation of chromosome separation
regulation of mitotic sister chromatid segregation
regulation of sister chromatid segregation
anaphase-promoting complex-dependent catabolic process
regulation of chromosome segregation
regulation of mitotic nuclear division
regulation of nuclear division
protein polyubiquitination
proteasome-mediated ubiquitin-dependent protein catabolic process
regulation of chromosome organization
proteasomal protein catabolic process
regulation of mitotic cell cycle phase transition
regulation of cell cycle phase transition
cell division
ubiquitin-dependent protein catabolic process
modification-dependent protein catabolic process
modification-dependent macromolecule catabolic process
proteolysis involved in cellular protein catabolic process
cellular protein catabolic process
regulation of mitotic cell cycle
protein catabolic process
protein ubiquitination
regulation of cell cycle process
protein modification by small protein conjugation
cellular macromolecule catabolic process
protein modification by small protein conjugation or removal
macromolecule catabolic process
organonitrogen compound catabolic process
regulation of cell cycle
proteolysis
regulation of organelle organization
cell cycle
organic substance catabolic process
cellular catabolic process