CERK

Entrez Summary: N/A
UniProt Summary: Catalyzes specifically the phosphorylation of ceramide to form ceramide 1-phosphate. Acts efficiently on natural and analog ceramides (C6, C8, C16 ceramides, and C8-dihydroceramide), to a lesser extent on C2-ceramide and C6-dihydroceramide, but not on other lipids, such as various sphingosines. Binds phosphoinositides. {ECO:0000269|PubMed:19168031}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Cyclosporin-A 0.8μM R07 exp347	-2.03
EPZ-5676 30μM R05 exp233	-1.95
Dimethyl-Sulfoxide 1pc R03 exp120	-1.78
KU-0063794 3.8μM R02 exp71	-1.74
Vinorelbine 0.001μM R05 exp249	1.75
Dynasore 7μM R08 exp436	1.82
CR131-b 0.005μM R08 exp474	2.04
MLN-4924 0.2μM R00 exp21	2.05
Docosahexaenoic-acid 50μM R07 exp356	2.12
YM155 0.001μM R08 exp432	2.19

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

dihydroceramide kinase activity
ceramide kinase activity
NAD+ kinase activity
glycosphingolipid metabolic process
lipid phosphorylation
ceramide metabolic process
glycolipid metabolic process
liposaccharide metabolic process
sphingolipid metabolic process
lipid modification
membrane lipid metabolic process
magnesium ion binding
cellular amide metabolic process
cellular lipid metabolic process
carbohydrate derivative metabolic process
lipid metabolic process
phosphorylation
ATP binding