CIDEB

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
2-Methoxyestradiol 0.55μM R07 exp310	1.71
Bisphenol F 50μM R08 exp457	1.72
Dexamethasone 0.006 to 0.015μM on day4 R07 exp352	1.74
Ammonium tetrathiomolybdate 10μM R08 exp448	1.88
RS-1 10μM R08 exp519	1.92

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

activation of cysteine-type endopeptidase activity
positive regulation of release of cytochrome c from mitochondria
zymogen activation
regulation of release of cytochrome c from mitochondria
execution phase of apoptosis
intrinsic apoptotic signaling pathway in response to DNA damage
lipid droplet
positive regulation of mitochondrion organization
intrinsic apoptotic signaling pathway
positive regulation of cysteine-type endopeptidase activity
protein processing
positive regulation of endopeptidase activity
positive regulation of apoptotic signaling pathway
regulation of mitochondrion organization
positive regulation of peptidase activity
protein maturation
regulation of cysteine-type endopeptidase activity
apoptotic signaling pathway
positive regulation of proteolysis
regulation of apoptotic signaling pathway
regulation of endopeptidase activity
regulation of peptidase activity
positive regulation of organelle organization
positive regulation of apoptotic process
positive regulation of programmed cell death
perinuclear region of cytoplasm
positive regulation of cell death
regulation of proteolysis
positive regulation of hydrolase activity
cellular response to DNA damage stimulus
apoptotic process
programmed cell death
identical protein binding
cell death
positive regulation of cellular component organization
proteolysis
regulation of hydrolase activity
regulation of organelle organization
positive regulation of catalytic activity
regulation of apoptotic process