CTBP1

Gene Information

Official Symbol: CTBP1
Official Name: C-terminal binding protein 1
Aliases and Previous Symbols: N/A
Entrez ID: 1487
UniProt: Q13363
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene encodes a protein that binds to the C-terminus of adenovirus E1A proteins. This phosphoprotein is a transcriptional repressor and may play a role during cellular proliferation. This protein and the product of a second closely related gene, CTBP2, can dimerize. Both proteins can also interact with a polycomb group protein complex which participates in regulation of gene expression during development. Alternative splicing of transcripts from this gene results in multiple transcript variants. [provided by RefSeq, Jul 2008].
UniProt Summary: Corepressor targeting diverse transcription regulators such as GLIS2 or BCL6. Has dehydrogenase activity. Involved in controlling the equilibrium between tubular and stacked structures in the Golgi complex. Functions in brown adipose tissue (BAT) differentiation. {ECO:0000269|PubMed:12419229, ECO:0000269|PubMed:15542832, ECO:0000269|PubMed:18212045, ECO:0000269|PubMed:19103759, ECO:0000269|PubMed:9858600}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
LY2090314 0.003μM R08 exp499	-2.3
LY2090314 0.003μM R08 exp500 no dilution day6	-2.21
Dynasore 10μM R04 exp180	-2
UMK57 1μM R01 exp59	-1.92
Ixabepilone 0.004 to 0.005μM on day4 R04 exp184	-1.75
TRAIL 50ng/ml R00 exp36	1.77
SNS-032 15μM R08 exp443	1.84
Asunaprenir 3μM R07 exp336	1.89
Rapamycin 2μM plus Cyclosporin-A 3μM R07 exp307	1.9
Tubacin 1.6μM R07 exp416	1.93

Global Fraction of Cell Lines Where Essential: 0/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/25
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/15
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/14
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/7
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 18540
Expression level (log2 read counts): 7.2

Expression Distribution

2-Hacid dh
2-Hacid dh C

negative regulation of histone H4 acetylation
white fat cell differentiation
regulation of histone H4 acetylation
presynaptic active zone cytoplasmic component
oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
negative regulation of histone acetylation
positive regulation of histone deacetylation
negative regulation of peptidyl-lysine acetylation
negative regulation of protein acetylation
positive regulation of protein deacetylation
viral genome replication
regulation of histone deacetylation
repressing transcription factor binding
NAD binding
negative regulation of histone modification
regulation of protein deacetylation
regulation of histone acetylation
transcriptional repressor complex
chromatin organization involved in negative regulation of transcription
chromatin silencing
negative regulation of chromatin organization
regulation of peptidyl-lysine acetylation
GABA-ergic synapse
chromatin organization involved in regulation of transcription
regulation of protein acetylation
negative regulation of gene expression, epigenetic
positive regulation of histone modification
positive regulation of chromatin organization
fat cell differentiation
negative regulation of chromosome organization
regulation of histone modification
gene silencing
positive regulation of chromosome organization
protein C-terminus binding
regulation of chromatin organization
viral life cycle
transcription factor complex
regulation of gene expression, epigenetic
transcription corepressor activity
protein domain specific binding