DAGLA

Entrez Summary: N/A
UniProt Summary: Catalyzes the hydrolysis of diacylglycerol (DAG) to 2- arachidonoyl-glycerol (2-AG), the most abundant endocannabinoid in tissues. Required for axonal growth during development and for retrograde synaptic signaling at mature synapses. {ECO:0000269|PubMed:14610053}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

endocannabinoid signaling pathway
retrograde trans-synaptic signaling by lipid
retrograde trans-synaptic signaling by endocannabinoid
diacylglycerol catabolic process
cannabinoid signaling pathway
trans-synaptic signaling by endocannabinoid
trans-synaptic signaling by lipid
retrograde trans-synaptic signaling
varicosity
G protein-coupled glutamate receptor signaling pathway
diacylglycerol metabolic process
neuroblast proliferation
neutral lipid catabolic process
acylglycerol catabolic process
neurotransmitter biosynthetic process
glutamate receptor signaling pathway
integral component of postsynaptic membrane
stem cell proliferation
glycerolipid catabolic process
arachidonic acid metabolic process
neural precursor cell proliferation
hydrolase activity
neurotransmitter metabolic process
acylglycerol metabolic process
neutral lipid metabolic process
unsaturated fatty acid metabolic process
icosanoid metabolic process
long-chain fatty acid metabolic process
fatty acid derivative metabolic process
cellular lipid catabolic process
postsynaptic membrane
lipid catabolic process
fatty acid metabolic process
regulation of neurotransmitter levels
glycerolipid metabolic process
trans-synaptic signaling
synaptic signaling
monocarboxylic acid metabolic process
cell population proliferation
carboxylic acid metabolic process