DCTN3

Entrez Summary: N/A
UniProt Summary: Together with dynein may be involved in spindle assembly and cytokinesis. {ECO:0000269|PubMed:9722614}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 182/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	2/28
blood	3/28
bone	5/26
breast	12/33
central nervous system	8/56
cervix	1/4
colorectal	3/17
esophagus	5/13
fibroblast	0/1
gastric	6/16
kidney	5/21
liver	6/20
lung	24/75
lymphocyte	4/16
ovary	6/26
pancreas	6/24
peripheral nervous system	6/16
plasma cell	2/15
prostate	0/1
skin	5/24
soft tissue	3/9
thyroid	0/2
upper aerodigestive	8/22
urinary tract	8/29
uterus	2/5

Expression Distribution

dynactin complex
cleavage furrow
condensed chromosome kinetochore
ciliary basal body-plasma membrane docking
cytoskeleton-dependent cytokinesis
antigen processing and presentation of exogenous peptide antigen via MHC class II
cytokinesis
antigen processing and presentation of peptide antigen via MHC class II
antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
spindle
G2/M transition of mitotic cell cycle
cell cycle G2/M phase transition
midbody
organelle localization by membrane tethering
antigen processing and presentation of exogenous peptide antigen
membrane docking
antigen processing and presentation of exogenous antigen
antigen processing and presentation of peptide antigen
structural molecule activity
regulation of G2/M transition of mitotic cell cycle
regulation of cell cycle G2/M phase transition
endoplasmic reticulum to Golgi vesicle-mediated transport
antigen processing and presentation
mitotic cell cycle phase transition
cell cycle phase transition
microtubule
cilium assembly
cilium organization
Golgi vesicle transport
regulation of mitotic cell cycle phase transition
plasma membrane bounded cell projection assembly
regulation of cell cycle phase transition
cell projection assembly
centrosome
cell division
organelle localization
mitotic cell cycle process
regulation of mitotic cell cycle
microtubule-based process
mitotic cell cycle