DNAH8

Entrez Summary: The protein encoded by this gene is a heavy chain of an axonemal dynein involved in sperm and respiratory cilia motility. Axonemal dyneins generate force through hydrolysis of ATP and binding to microtubules. [provided by RefSeq, Jan 2012].
UniProt Summary: Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Involved in sperm motility; implicated in sperm flagellar assembly (By similarity). {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Expression Distribution

Screen	Score
SGC2096 2.6μM R03 exp153	-2.09
∆-9-Tetrahydrocannabinol 30μM R08 exp445	1.72
Olaparib 4μM R08 exp512	1.83
UM131593 0.1μM R01 exp58	2.42

outer dynein arm
axonemal dynein complex
outer dynein arm assembly
ATP-dependent microtubule motor activity, minus-end-directed
dynein complex
dynein light chain binding
dynein light intermediate chain binding
dynein intermediate chain binding
axonemal dynein complex assembly
axoneme assembly
microtubule motor activity
microtubule bundle formation
cilium or flagellum-dependent cell motility
cilium-dependent cell motility
microtubule-based movement
microtubule
cilium assembly
cilium organization
plasma membrane bounded cell projection assembly
cell projection assembly
microtubule cytoskeleton organization
microtubule-based process
organelle assembly
cellular protein-containing complex assembly
localization of cell
cell motility
cytoskeleton organization
plasma membrane bounded cell projection organization
cell projection organization
locomotion
ATP binding
movement of cell or subcellular component
protein-containing complex assembly
protein-containing complex subunit organization