EDC3

Entrez Summary: This gene encodes a protein that is important in mRNA degradation. The encoded protein is a component of a decapping complex that promotes efficient removal of the monomethylguanosine (m7G) cap from mRNAs, as part of the 5' to 3' mRNA decay pathway. Mutations in this gene have been identified in human patients with an autosomal recessive form of intellectual disability. [provided by RefSeq, May 2017].
UniProt Summary: Binds single-stranded RNA. Involved in the process of mRNA degradation and in the positive regulation of mRNA decapping. May play a role in spermiogenesis and oogenesis. {ECO:0000269|PubMed:16364915, ECO:0000269|PubMed:17533573, ECO:0000269|PubMed:18678652, ECO:0000269|PubMed:25701870}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
CB-839 10μM R05 exp224	-2.27
3-Bromopyruvate 7μM R04 exp175	-1.96
Docosahexaenoic-acid 50μM R07 exp356	-1.89
Colchicine 0.009μM R05 exp215	-1.81
UM0131023 0.05μM R05 exp248	-1.72
Rapamycin 2μM R07 exp306	1.77
INK128 0.2μM R02 exp70	1.9
Hippuristanol 0.12μM R08 exp488	2.04
Hippuristanol 0.12μM R08 exp489 no dilution day6	2.29

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

phosphodiesterase decapping endonuclease activity
deadenylation-independent decapping of nuclear-transcribed mRNA
nuclear-transcribed mRNA catabolic process, deadenylation-independent decay
cytoplasmic mRNA processing body assembly
exonucleolytic catabolism of deadenylated mRNA
nuclear-transcribed mRNA catabolic process, exonucleolytic
nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
cytoplasmic ribonucleoprotein granule
RNA phosphodiester bond hydrolysis, endonucleolytic
P-body
RNA phosphodiester bond hydrolysis
mRNA binding
nuclear-transcribed mRNA catabolic process
mRNA catabolic process
ribonucleoprotein complex assembly
ribonucleoprotein complex subunit organization
RNA catabolic process
nucleic acid phosphodiester bond hydrolysis
nucleobase-containing compound catabolic process
heterocycle catabolic process
cellular nitrogen compound catabolic process
aromatic compound catabolic process
ribonucleoprotein complex biogenesis
organic cyclic compound catabolic process
mRNA metabolic process
organelle assembly
cellular protein-containing complex assembly
cellular macromolecule catabolic process
macromolecule catabolic process
identical protein binding
protein-containing complex assembly
RNA metabolic process
negative regulation of gene expression
organic substance catabolic process
cellular catabolic process
protein-containing complex subunit organization
membrane