EGFR
Gene Information
- Official Symbol: EGFR
- Official Name: epidermal growth factor receptor
- Aliases and Previous Symbols: N/A
- Entrez ID: 1956
- UniProt: P00533
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily. This protein is a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that binds to epidermal growth factor. Binding of the protein to a ligand induces receptor dimerization and tyrosine autophosphorylation and leads to cell proliferation. Mutations in this gene are associated with lung cancer. [provided by RefSeq, Jun 2016].
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| Recep L domain |
| Furin-like |
| Pkinase Tyr |
| Pkinase |
GO Terms
| multivesicular body, internal vesicle lumen |
| epidermal growth factor-activated receptor activity |
| activation of phospholipase A2 activity by calcium-mediated signaling |
| Shc-EGFR complex |
| positive regulation of prolactin secretion |
| response to cobalamin |
| activation of phospholipase A2 activity |
| epidermal growth factor binding |
| response to hydroxyisoflavone |
| positive regulation of nitric oxide mediated signal transduction |
| response to phenylpropanoid |
| positive regulation of protein kinase C activity |
| regulation of protein kinase C activity |
| positive regulation of phospholipase A2 activity |
| response to UV-A |
| nitric-oxide synthase regulator activity |
| positive regulation of production of miRNAs involved in gene silencing by miRNA |
| regulation of nitric oxide mediated signal transduction |
| regulation of phospholipase A2 activity |
| magnesium ion homeostasis |
| midgut development |
| eyelid development in camera-type eye |
| morphogenesis of an epithelial fold |
| positive regulation of bone resorption |
| positive regulation of bone remodeling |
| MAP kinase kinase kinase activity |
| regulation of production of miRNAs involved in gene silencing by miRNA |
| positive regulation of superoxide anion generation |
| astrocyte activation |
| tongue development |
| regulation of production of small RNA involved in gene silencing by RNA |
| negative regulation of cardiocyte differentiation |
| regulation of superoxide anion generation |
| positive regulation of gene silencing by miRNA |
| positive regulation of posttranscriptional gene silencing |
| salivary gland morphogenesis |
| liver regeneration |
| cellular response to dexamethasone stimulus |
| positive regulation of cyclin-dependent protein serine/threonine kinase activity |
| positive regulation of tissue remodeling |
| activation of phospholipase C activity |
| positive regulation of vasoconstriction |
| ERBB2 signaling pathway |
| salivary gland development |
| positive regulation of synaptic transmission, glutamatergic |
| peptidyl-tyrosine autophosphorylation |
| regulation of superoxide metabolic process |
| basal plasma membrane |
| positive regulation of cyclin-dependent protein kinase activity |
| astrocyte development |
| positive regulation of DNA replication |
| positive regulation of G1/S transition of mitotic cell cycle |
| cellular response to estradiol stimulus |
| protein insertion into membrane |
| cellular response to cadmium ion |
| hydrogen peroxide metabolic process |
| glial cell activation |
| regulation of bone resorption |
| response to dexamethasone |
| neuroinflammatory response |
| negative regulation of Notch signaling pathway |
| cerebral cortex cell migration |
| positive regulation of phospholipase C activity |
| cellular response to epidermal growth factor stimulus |
| exocrine system development |
| regulation of nitric-oxide synthase activity |
| negative regulation of epidermal growth factor receptor signaling pathway |
| regulation of phospholipase C activity |
| positive regulation of cell cycle G1/S phase transition |
| response to epidermal growth factor |
| digestive tract morphogenesis |
| regulation of bone remodeling |
| regulation of cardiocyte differentiation |
| epidermal growth factor receptor signaling pathway |
| positive regulation of fibroblast proliferation |
| negative regulation of ERBB signaling pathway |
| astrocyte differentiation |
| clathrin-coated vesicle membrane |
| activation of MAPKK activity |
| regulation of monooxygenase activity |
| transmembrane receptor protein tyrosine kinase activity |
| positive regulation of protein localization to plasma membrane |
| cellular response to glucocorticoid stimulus |
| regulation of vasoconstriction |
| positive regulation of blood vessel diameter |
| telencephalon cell migration |
| endocytic vesicle |
| cellular response to corticosteroid stimulus |
| positive regulation of phospholipase activity |
| forebrain cell migration |
| positive regulation of protein localization to cell periphery |
| response to cadmium ion |
| positive regulation of DNA repair |
| ovulation cycle |
| regulation of synaptic transmission, glutamatergic |
| cellular response to amino acid stimulus |
| positive regulation of blood circulation |
| ERBB signaling pathway |
| hair follicle development |
| regulation of phospholipase activity |
| positive regulation of lipase activity |
| regulation of tissue remodeling |
| animal organ regeneration |
| skin epidermis development |
| molting cycle process |
| hair cycle process |
| virus receptor activity |
| response to osmotic stress |
| positive regulation of NIK/NF-kappaB signaling |
| positive regulation of mitotic cell cycle phase transition |
| cellular response to mechanical stimulus |
| regulation of fibroblast proliferation |
| regulation of epidermal growth factor receptor signaling pathway |
| protein phosphatase binding |
| positive regulation of smooth muscle cell proliferation |
| embryonic placenta development |
| response to vitamin |
| regulation of gene silencing by miRNA |
| protein tyrosine kinase activity |
| regulation of posttranscriptional gene silencing |
| regulation of gene silencing by RNA |
| regulation of ERBB signaling pathway |
| cellular response to ketone |
| molting cycle |
| hair cycle |
| positive regulation of cell cycle phase transition |
| response to antineoplastic agent |
| viral entry into host cell |
| regulation of protein localization to plasma membrane |
| regulation of oxidoreductase activity |
| positive regulation of reactive oxygen species metabolic process |
| positive regulation of peptide hormone secretion |
| regulation of lipase activity |
| regulation of cyclin-dependent protein serine/threonine kinase activity |
| positive regulation of response to DNA damage stimulus |
| gland morphogenesis |
| regulation of cyclin-dependent protein kinase activity |
| double-stranded DNA binding |
| entry into host cell |
| entry into host |
| regulation of Notch signaling pathway |
| antibiotic metabolic process |
| positive regulation of peptidyl-serine phosphorylation |
| glial cell development |
| regulation of DNA replication |
| diterpenoid metabolic process |
| regulation of NIK/NF-kappaB signaling |
| reactive oxygen species metabolic process |
| response to amino acid |
| regulation of protein localization to cell periphery |
| cerebral cortex development |
| regulation of phosphatidylinositol 3-kinase signaling |
| terpenoid metabolic process |
| positive regulation of protein localization to membrane |
| regulation of DNA repair |
| liver development |
| positive regulation of hormone secretion |
| regulation of gene silencing |
| hepaticobiliary system development |
| integrin binding |
| digestive tract development |
| cellular response to reactive oxygen species |
| negative regulation of protein catabolic process |
| regulation of smooth muscle cell proliferation |
| response to estradiol |
| regulation of peptidyl-serine phosphorylation |
| transmembrane signaling receptor activity |
| isoprenoid metabolic process |
| positive regulation of inflammatory response |
| regulation of blood vessel diameter |
| regulation of tube diameter |
| regulation of tube size |
| circadian rhythm |
| digestive system development |
| response to UV |
| positive regulation of canonical Wnt signaling pathway |
| peptidyl-tyrosine phosphorylation |
| response to glucocorticoid |
| calcium-mediated signaling |
| peptidyl-tyrosine modification |
| regulation of G1/S transition of mitotic cell cycle |
| response to calcium ion |
| positive regulation of synaptic transmission |
| positive regulation of mitotic cell cycle |
| placenta development |
| early endosome membrane |
| regeneration |
| interaction with host |
| response to corticosteroid |
| positive regulation of cell growth |
| positive regulation of protein kinase B signaling |
| regulation of cell cycle G1/S phase transition |
| lung development |
| vascular process in circulatory system |
| glial cell differentiation |
| respiratory tube development |
| pallium development |
| positive regulation of Wnt signaling pathway |
| regulation of reactive oxygen species metabolic process |
| regulation of JNK cascade |
| cellular response to xenobiotic stimulus |
| cellular response to steroid hormone stimulus |
| regulation of protein localization to membrane |
| positive regulation of epithelial cell proliferation |
| cellular response to metal ion |
| positive regulation of DNA metabolic process |
| protein autophosphorylation |
| response to ketone |
| response to reactive oxygen species |
| respiratory system development |
| basolateral plasma membrane |
| viral life cycle |
| calmodulin binding |
| actin filament binding |
| receptor complex |
| cellular response to acid chemical |
| regulation of peptide hormone secretion |
| positive regulation of ERK1 and ERK2 cascade |
| endosome membrane |
| response to mechanical stimulus |
| gliogenesis |
| response to nutrient |
| regulation of response to DNA damage stimulus |
| regulation of protein kinase B signaling |
| cellular response to inorganic substance |
| membrane raft |
| regulation of stress-activated MAPK cascade |
| regulation of stress-activated protein kinase signaling cascade |
| nuclear membrane |
| cellular response to oxidative stress |
| regulation of peptidyl-tyrosine phosphorylation |
| telencephalon development |
| learning or memory |
| positive regulation of growth |
| positive regulation of MAP kinase activity |
| ossification |
| establishment of protein localization to membrane |
| regulation of hormone secretion |
| synapse |
| positive regulation of protein secretion |
| endosome |
| rhythmic process |
| regulation of canonical Wnt signaling pathway |
| positive regulation of cell cycle process |
| regulation of blood circulation |
| positive regulation of peptide secretion |
| regulation of ERK1 and ERK2 cascade |
| ubiquitin protein ligase binding |
| cognition |
| response to xenobiotic stimulus |
| negative regulation of mitotic cell cycle |
| response to light stimulus |
| cadherin binding |
| negative regulation of catabolic process |
| camera-type eye development |
| cellular response to environmental stimulus |
| cellular response to abiotic stimulus |
| apical plasma membrane |
| positive regulation of cellular protein localization |
| response to steroid hormone |
| activation of protein kinase activity |
| regulation of epithelial cell proliferation |
| cellular response to external stimulus |
| second-messenger-mediated signaling |
| regulation of inflammatory response |
| positive regulation of protein serine/threonine kinase activity |
| regulation of MAP kinase activity |
| response to acid chemical |
| enzyme binding |
| regulation of DNA metabolic process |
| eye development |
| visual system development |
| regulation of Wnt signaling pathway |
| sensory system development |
| response to metal ion |
| MAPK cascade |
| positive regulation of cell cycle |
| in utero embryonic development |
| translation |
| skin development |
| regulation of protein catabolic process |
| response to oxidative stress |
| forebrain development |
| blood circulation |
| signal transduction by protein phosphorylation |
| chromatin binding |
| circulatory system process |
| cellular response to drug |
| positive regulation of secretion by cell |
| peptide biosynthetic process |
| gland development |
| regulation of mitotic cell cycle phase transition |
| epidermis development |
| focal adhesion |
| regulation of cell growth |
| reproductive structure development |
| positive regulation of protein transport |
| reproductive system development |
| morphogenesis of an epithelium |
| embryonic organ development |
| positive regulation of secretion |
| cofactor metabolic process |
| response to radiation |
| modulation of chemical synaptic transmission |
| regulation of trans-synaptic signaling |
| regulation of cell cycle phase transition |
| positive regulation of establishment of protein localization |
| protein kinase binding |
| regulation of protein secretion |
| positive regulation of defense response |
| wound healing |
| protein localization to membrane |
| neuron projection morphogenesis |
| plasma membrane bounded cell projection morphogenesis |
| protein heterodimerization activity |
| divalent inorganic cation homeostasis |
| cell projection morphogenesis |
| regulation of peptide secretion |
| response to nutrient levels |
| inflammatory response |
| cellular response to growth factor stimulus |
| drug metabolic process |
| positive regulation of cell migration |
| cell-cell adhesion |
| transmembrane receptor protein tyrosine kinase signaling pathway |
| cell part morphogenesis |
| regulation of anatomical structure size |
| regulation of protein serine/threonine kinase activity |
| cellular response to lipid |
| positive regulation of cell motility |
| amide biosynthetic process |
| peptide metabolic process |
| response to extracellular stimulus |
| response to growth factor |
| regulation of hormone levels |
| positive regulation of protein kinase activity |
| response to inorganic substance |
| positive regulation of cellular component movement |
| regulation of cellular protein localization |
| cellular response to organic cyclic compound |
| positive regulation of MAPK cascade |
| sensory organ development |
| positive regulation of locomotion |
| cell population proliferation |
| tissue morphogenesis |
| behavior |
| response to wounding |
| negative regulation of cell cycle |
| positive regulation of kinase activity |
| regulation of system process |
| protein-containing complex |
| cellular response to organonitrogen compound |
| positive regulation of response to external stimulus |
| cellular response to hormone stimulus |
| cell surface |
| Golgi membrane |
| metal ion homeostasis |
| regulation of mitotic cell cycle |
| chordate embryonic development |
| embryo development ending in birth or egg hatching |
| tube morphogenesis |
| positive regulation of transferase activity |
| cellular response to nitrogen compound |
| neuron projection development |
| developmental process involved in reproduction |
| regulation of growth |
| perinuclear region of cytoplasm |
| viral process |
| cation homeostasis |
| regulation of protein transport |
| negative regulation of cell differentiation |
| enzyme linked receptor protein signaling pathway |
| inorganic ion homeostasis |
| cell morphogenesis |
| regulation of cellular response to stress |
| regulation of peptide transport |
| brain development |
| regulation of establishment of protein localization |
| regulation of secretion by cell |
| regulation of cell cycle process |
| regulation of MAPK cascade |
| regulation of defense response |
| positive regulation of hydrolase activity |
| head development |
| symbiotic process |
| ion homeostasis |
| cellular amide metabolic process |
| regulation of protein kinase activity |
| regulation of secretion |
| neuron development |
| interspecies interaction between organisms |
| cellular component morphogenesis |
| multicellular organismal reproductive process |
| multicellular organism reproduction |
| tube development |
| regulation of cell migration |
| membrane organization |
| response to lipid |
| regulation of kinase activity |
| peptidyl-amino acid modification |
| negative regulation of apoptotic process |
| negative regulation of programmed cell death |
| response to hormone |
| regulation of cell motility |
| regulation of cellular localization |
| positive regulation of cell population proliferation |
| response to organic cyclic compound |
| cell adhesion |
| biological adhesion |
| endoplasmic reticulum membrane |
| negative regulation of developmental process |
| cellular lipid metabolic process |
| animal organ morphogenesis |
| cell migration |
| protein phosphorylation |
| embryo development |
| regulation of transferase activity |
| central nervous system development |
| regulation of locomotion |
| positive regulation of transport |
| negative regulation of cell death |
| regulation of catabolic process |
| regulation of cellular component movement |
| response to organonitrogen compound |
| neuron differentiation |
| positive regulation of protein phosphorylation |
| response to drug |
| positive regulation of intracellular signal transduction |
| regulation of protein localization |
| cellular response to oxygen-containing compound |
| positive regulation of phosphorylation |
| identical protein binding |
| cell activation |
| cell motility |
| localization of cell |
| response to nitrogen compound |
| regulation of response to external stimulus |
| negative regulation of protein metabolic process |
| chemical homeostasis |
| epithelium development |
| plasma membrane bounded cell projection organization |
| positive regulation of phosphorus metabolic process |
| positive regulation of phosphate metabolic process |
| cell projection organization |
| response to abiotic stimulus |
| regulation of cell cycle |
| negative regulation of multicellular organismal process |
| lipid metabolic process |
| positive regulation of transcription by RNA polymerase II |
| cellular response to endogenous stimulus |
| positive regulation of protein modification process |
| negative regulation of signal transduction |
| regulation of hydrolase activity |
| phosphorylation |
| locomotion |
| defense response |
| negative regulation of cell communication |
| negative regulation of signaling |
| nervous system process |
| integral component of plasma membrane |
| organonitrogen compound biosynthetic process |
| reproductive process |
| reproduction |
| positive regulation of catalytic activity |
| regulation of protein phosphorylation |
| response to endogenous stimulus |
| regulation of response to stress |
| ATP binding |
| generation of neurons |
| positive regulation of transcription, DNA-templated |
| regulation of apoptotic process |
| movement of cell or subcellular component |
| response to oxygen-containing compound |
| regulation of programmed cell death |
| cellular protein localization |
| regulation of phosphorylation |
| extracellular space |
| cellular macromolecule localization |
| positive regulation of cellular protein metabolic process |
| establishment of protein localization |
| regulation of cell population proliferation |
| negative regulation of response to stimulus |
| neurogenesis |
| cellular nitrogen compound biosynthetic process |
| positive regulation of nucleic acid-templated transcription |
| positive regulation of RNA biosynthetic process |
| homeostatic process |
| cell development |
| positive regulation of signal transduction |
| regulation of cell death |
| intracellular signal transduction |
| cellular response to stress |
| positive regulation of protein metabolic process |
| cellular macromolecule biosynthetic process |
| positive regulation of RNA metabolic process |
| positive regulation of multicellular organismal process |
| tissue development |
| macromolecule biosynthetic process |
| positive regulation of molecular function |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| regulation of cell differentiation |
| positive regulation of cell communication |
| positive regulation of signaling |
| regulation of intracellular signal transduction |
| regulation of protein modification process |
| regulation of transport |
| positive regulation of nucleobase-containing compound metabolic process |
| positive regulation of macromolecule biosynthetic process |
| system process |
| positive regulation of cellular biosynthetic process |
| positive regulation of gene expression |
| membrane |
| gene expression |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| DABN racemic mixture R03 exp93 | 1.79 |
| Nocodazole 0.2μM R00 exp24 | 1.93 |
| Rotenone 2μM R00 exp33 | 1.95 |
| SB743921 0.001μM R05 exp244 | 1.99 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 9/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 2/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 1/20 |
| lung | 2/75 |
| lymphocyte | 0/16 |
| ovary | 1/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 1/22 |
| urinary tract | 1/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 11250
- Expression level (log2 read counts): -1.56
Expression Distribution
EGFR Expression in NALM6 Cells: -1.56
