EHMT1

Gene Information

Official Symbol: EHMT1
Official Name: euchromatic histone lysine methyltransferase 1
Aliases and Previous Symbols: N/A
Entrez ID: 79813
UniProt: Q9H9B1
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: The protein encoded by this gene is a histone methyltransferase that methylates the lysine-9 position of histone H3. This action marks the genomic region packaged with these methylated histones for transcriptional repression. This protein may be involved in the silencing of MYC- and E2F-responsive genes and therefore could play a role in the G0/G1 cell cycle transition. Defects in this gene are a cause of chromosome 9q subtelomeric deletion syndrome (9q-syndrome, also known as Kleefstra syndrome). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2017].
UniProt Summary: Histone methyltransferase that specifically mono- and dimethylates 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin. H3K9me represents a specific tag for epigenetic transcriptional repression by recruiting HP1 proteins to methylated histones. Also weakly methylates 'Lys-27' of histone H3 (H3K27me). Also required for DNA methylation, the histone methyltransferase activity is not required for DNA methylation, suggesting that these 2 activities function independently. Probably targeted to histone H3 by different DNA-binding proteins like E2F6, MGA, MAX and/or DP1. During G0 phase, it probably contributes to silencing of MYC- and E2F-responsive genes, suggesting a role in G0/G1 transition in cell cycle. In addition to the histone methyltransferase activity, also methylates non- histone proteins: mediates dimethylation of 'Lys-373' of p53/TP53. {ECO:0000269|PubMed:12004135, ECO:0000269|PubMed:20118233}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/25
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/15
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/14
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/7
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 1858
Expression level (log2 read counts): 6.89

Expression Distribution

Screen	Score
CAY10603 0.55μM R08 exp467	1.79
Cerivastatin 0.15μM R05 exp226	1.92
3-Bromopyruvate 7μM R04 exp175	2.44
UM131593 0.2μM R03 exp106	2.64

SET
Pre-SET
Ank
Ank 2

histone methyltransferase activity (H3-K27 specific)
histone methyltransferase activity (H3-K9 specific)
response to fungicide
peptidyl-lysine monomethylation
histone H3-K27 methylation
peptidyl-lysine dimethylation
C2H2 zinc finger domain binding
histone H3-K9 methylation
histone-lysine N-methyltransferase activity
histone H3-K9 modification
protein-lysine N-methyltransferase activity
negative regulation of G0 to G1 transition
regulation of G0 to G1 transition
DNA methylation
DNA alkylation
methyltransferase activity
DNA methylation or demethylation
p53 binding
histone lysine methylation
DNA modification
peptidyl-lysine methylation
histone methylation
positive regulation of cold-induced thermogenesis
chromosome
regulation of embryonic development
protein alkylation
protein methylation
regulation of cold-induced thermogenesis
regulation of signal transduction by p53 class mediator
macromolecule methylation
nuclear body
response to antibiotic
methylation
peptidyl-lysine modification
negative regulation of cell cycle process
histone modification
covalent chromatin modification
response to toxic substance
negative regulation of cell cycle
chromatin organization