ENPP4

Entrez Summary: N/A
UniProt Summary: Hydrolyzes extracellular Ap3A into AMP and ADP, and Ap4A into AMP and ATP. Ap3A and Ap4A are diadenosine polyphosphates thought to induce proliferation of vascular smooth muscle cells. Acts as a procoagulant, mediating platelet aggregation at the site of nascent thrombus via release of ADP from Ap3A and activation of ADP receptors. {ECO:0000269|PubMed:22995898, ECO:0000269|PubMed:24338010}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

bis(5-adenosyl)-triphosphatase activity
purine ribonucleoside catabolic process
purine nucleoside catabolic process
ribonucleoside catabolic process
positive regulation of blood coagulation
positive regulation of hemostasis
positive regulation of coagulation
nucleoside catabolic process
glycosyl compound catabolic process
nucleobase-containing small molecule catabolic process
purine-containing compound catabolic process
positive regulation of wound healing
ficolin-1-rich granule membrane
purine ribonucleoside metabolic process
positive regulation of response to wounding
purine nucleoside metabolic process
ribonucleoside metabolic process
regulation of blood coagulation
regulation of hemostasis
regulation of coagulation
nucleoside metabolic process
glycosyl compound metabolic process
regulation of wound healing
regulation of response to wounding
carbohydrate derivative catabolic process
blood coagulation
coagulation
hemostasis
purine-containing compound metabolic process
nucleobase-containing compound catabolic process
heterocycle catabolic process
cellular nitrogen compound catabolic process
small molecule catabolic process
aromatic compound catabolic process
wound healing
organic cyclic compound catabolic process
neutrophil degranulation
neutrophil activation involved in immune response
regulation of body fluid levels
neutrophil mediated immunity