FBXL17

Entrez Summary: N/A
UniProt Summary: Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex. {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
2-Methoxyestradiol 0.55 to 1μM on day4 R07 exp312	1.7
Aphidicolin 0.04μM R06 exp263	1.73
TRAIL 50ng/ml R00 exp36	3.11
TRAIL 5ng/ml R00 exp35	3.67

F-box-like
F-box

protein quality control for misfolded or incompletely synthesized proteins
SCF ubiquitin ligase complex
regulation of smoothened signaling pathway
neural crest cell differentiation
SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
mesenchymal cell differentiation
stem cell differentiation
mesenchyme development
ubiquitin protein ligase activity
protein polyubiquitination
proteasome-mediated ubiquitin-dependent protein catabolic process
proteasomal protein catabolic process
ubiquitin-dependent protein catabolic process
modification-dependent protein catabolic process
modification-dependent macromolecule catabolic process
proteolysis involved in cellular protein catabolic process
cellular protein catabolic process
protein catabolic process
protein ubiquitination
protein modification by small protein conjugation
cellular macromolecule catabolic process
protein modification by small protein conjugation or removal
macromolecule catabolic process
organonitrogen compound catabolic process
proteolysis
tissue development
organic substance catabolic process
cellular catabolic process