FBXW11

Gene Information

Official Symbol: FBXW11
Official Name: F-box and WD repeat domain containing 11
Aliases and Previous Symbols: N/A
Entrez ID: 23291
UniProt: Q9UKB1
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbws class and, in addition to an F-box, contains multiple WD40 repeats. This gene contains at least 14 exons, and its alternative splicing generates 3 transcript variants diverging at the presence/absence of two alternate exons. [provided by RefSeq, Jul 2008].
UniProt Summary: Substrate recognition component of a SCF (SKP1-CUL1-F- box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins. SCF(FBXW11) mediates the ubiquitination of phosphorylated CTNNB1 and participates in Wnt signaling. SCF(FBXW11) mediates the ubiquitination of phosphorylated NFKBIA, which degradation frees the associated NFKB1 to translocate into the nucleus and to activate transcription. SCF(FBXW11) mediates the ubiquitination of IFNAR1. SCF(FBXW11) mediates the ubiquitination of CEP68; this is required for centriole separation during mitosis (PubMed:25503564). Involved in the oxidative stress-induced a ubiquitin-mediated decrease in RCAN1. Mediates the degradation of CDC25A induced by ionizing radiation in cells progressing through S phase and thus may function in the intra-S- phase checkpoint. Has an essential role in the control of the clock-dependent transcription via degradation of phosphorylated PER1 and phosphorylated PER2. Is target of human immunodeficiency virus type 1 (HIV-1) protein VPU to polyubiquitinate and deplete BST2 from cells and antagonize its antiviral action. {ECO:0000269|PubMed:10321728, ECO:0000269|PubMed:10437795, ECO:0000269|PubMed:10644755, ECO:0000269|PubMed:10648623, ECO:0000269|PubMed:14532120, ECO:0000269|PubMed:14603323, ECO:0000269|PubMed:15917222, ECO:0000269|PubMed:18575781, ECO:0000269|PubMed:19730691, ECO:0000269|PubMed:19966869, ECO:0000269|PubMed:20347421, ECO:0000269|PubMed:25503564}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
LY2090314 0.003μM R08 exp500 no dilution day6	-2.31
Trichostatin-A 0.06μM R07 exp415	-2.08
Dexamethasone 0.006 to 0.015μM on day4 R07 exp352	1.71
Cyclosporin-A 0.8μM R07 exp347	1.76
Resminostat 0.5μM R07 exp393	1.76
GSK-J4 1-1.25μM to day4 R07 exp363	1.86
Dynasore 10μM R04 exp180	1.89
Pifithrin-alpha 20μM R07 exp390	2.08
Vemurafenib 6.6μM R02 exp89	2.32
Erlotinib 10μM R05 exp216	2.39
Rifampicin 30μM R08 exp430	2.66

Global Fraction of Cell Lines Where Essential: 29/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	1/28
blood	5/28
bone	1/26
breast	4/33
central nervous system	2/56
cervix	0/4
colorectal	1/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	1/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	1/15
prostate	0/1
skin	2/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	1/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 564
Expression level (log2 read counts): 5.52

Expression Distribution

WD40
F-box
F-box-like
Beta-TrCP D

positive regulation of circadian rhythm
negative regulation of NIK/NF-kappaB signaling
protein destabilization
SCF ubiquitin ligase complex
NIK/NF-kappaB signaling
SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
interleukin-1-mediated signaling pathway
ubiquitin ligase complex
stress-activated MAPK cascade
regulation of NIK/NF-kappaB signaling
stimulatory C-type lectin receptor signaling pathway
regulation of circadian rhythm
innate immune response activating cell surface receptor signaling pathway
G2/M transition of mitotic cell cycle
cell cycle G2/M phase transition
stress-activated protein kinase signaling cascade
protein dimerization activity
Fc-epsilon receptor signaling pathway
cellular response to interleukin-1
T cell receptor signaling pathway
response to interleukin-1
protein dephosphorylation
ubiquitin protein ligase activity
innate immune response-activating signal transduction
Fc receptor signaling pathway
ubiquitin-protein transferase activity
activation of innate immune response
mitotic cell cycle phase transition
rhythmic process
cell cycle phase transition
regulation of protein stability
antigen receptor-mediated signaling pathway
protein polyubiquitination
dephosphorylation
proteasome-mediated ubiquitin-dependent protein catabolic process
positive regulation of innate immune response
proteasomal protein catabolic process
positive regulation of proteolysis
cell-cell signaling by wnt
Wnt signaling pathway