FCGR3B
Gene Information
- Official Symbol: FCGR3B
- Official Name: Fc fragment of IgG receptor IIIb
- Aliases and Previous Symbols: N/A
- Entrez ID: 2215
- UniProt: O75015
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: The protein encoded by this gene is a low affinity receptor for the Fc region of gamma immunoglobulins (IgG). The encoded protein acts as a monomer and can bind either monomeric or aggregated IgG. This gene may function to capture immune complexes in the peripheral circulation. Several transcript variants encoding different isoforms have been found for this gene. A highly-similar gene encoding a related protein is also found on chromosome 1. [provided by RefSeq, Aug 2012].
- UniProt Summary: Receptor for the Fc region of immunoglobulins gamma. Low affinity receptor. Binds complexed or aggregated IgG and also monomeric IgG. Contrary to III-A, is not capable to mediate antibody-dependent cytotoxicity and phagocytosis. May serve as a trap for immune complexes in the peripheral circulation which does not activate neutrophils.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 19070
- Expression level (log2 read counts): -7.68
FCGR3B Expression in NALM6 Cells: -7.68
