FOXA2

Gene Information

Official Symbol: FOXA2
Official Name: forkhead box A2
Aliases and Previous Symbols: N/A
Entrez ID: 3170
UniProt: Q9Y261
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Transcription factor that is involved in embryonic development, establishment of tissue-specific gene expression and regulation of gene expression in differentiated tissues. Is thought to act as a 'pioneer' factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites. Binds DNA with the consensus sequence 5'-[AC]A[AT]T[AG]TT[GT][AG][CT]T[CT]-3' (By similarity). In embryonic development is required for notochord formation. Involved in the development of multiple endoderm-derived organ systems such as the liver, pancreas and lungs; FOXA1 and FOXA2 seem to have at least in part redundant roles. Originally described as a transcription activator for a number of liver genes such as AFP, albumin, tyrosine aminotransferase, PEPCK, etc. Interacts with the cis-acting regulatory regions of these genes. Involved in glucose homeostasis; regulates the expression of genes important for glucose sensing in pancreatic beta-cells and glucose homeostasis. Involved in regulation of fat metabolism. Binds to fibrinogen beta promoter and is involved in IL6-induced fibrinogen beta transcriptional activation. {ECO:0000250}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 5/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	3/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	1/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 7701
Expression level (log2 read counts): -5.6

Expression Distribution

Fork head
Fork head N
HNF C

negative regulation of transcription by glucose
negative regulation of detection of glucose
regulation of detection of glucose
negative regulation of transcription from RNA polymerase II promoter by glucose
regulation of transcription from RNA polymerase II promoter by glucose
positive regulation of transcription from RNA polymerase II promoter by glucose
carbon catabolite activation of transcription from RNA polymerase II promoter
carbon catabolite regulation of transcription from RNA polymerase II promoter
positive regulation of transcription by glucose
negative regulation of hexokinase activity
regulation of transcription by glucose
negative regulation of glucokinase activity
carbon catabolite regulation of transcription
carbon catabolite activation of transcription
positive regulation of gastrulation
regulation of glucokinase activity
primitive streak formation
positive regulation of cell-cell adhesion mediated by cadherin
regulation of hexokinase activity
regulation of cell-cell adhesion mediated by cadherin
negative regulation of epithelial to mesenchymal transition
gastrulation with mouth forming second
dopaminergic neuron differentiation
response to interleukin-6
positive regulation of embryonic development
regulation of gastrulation
endocrine pancreas development
negative regulation of cellular carbohydrate metabolic process
negative regulation of carbohydrate metabolic process
anterior/posterior axis specification
regulation of insulin secretion involved in cellular response to glucose stimulus
cellular response to nutrient
pancreas development
adult locomotory behavior
regulation of blood coagulation
regulation of hemostasis
regulation of coagulation
regulation of epithelial to mesenchymal transition
axis specification
cell fate specification