GPS1

Entrez Summary: N/A
UniProt Summary: Essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN- dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Suppresses G- protein- and mitogen-activated protein kinase-mediated signal transduction. {ECO:0000269|PubMed:11285227, ECO:0000269|PubMed:11337588, ECO:0000269|PubMed:12628923, ECO:0000269|PubMed:12732143, ECO:0000269|PubMed:9535219}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Arsenate 40μM R06 exp264	-1.91
∆-9-Tetrahydrocannabinol 30μM R08 exp445	-1.74
Ethanol 0.003 R08 exp437	1.82
Epigallocatechin gallate 20μM R05 exp230	1.94
MLN-4924 0.2μM R00 exp21	2.01
Pyridostatin 4μM R05 exp240	2.04
YM155 0.001μM R08 exp432	2.08
Etoposide 0.1μM R05 exp198	3.03

Global Fraction of Cell Lines Where Essential: 557/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	1/1
bile duct	22/28
blood	21/28
bone	17/26
breast	26/33
central nervous system	35/56
cervix	4/4
colorectal	13/17
esophagus	12/13
fibroblast	1/1
gastric	12/16
kidney	15/21
liver	14/20
lung	60/75
lymphocyte	11/16
ovary	21/26
pancreas	22/24
peripheral nervous system	6/16
plasma cell	11/15
prostate	1/1
skin	14/24
soft tissue	9/9
thyroid	1/2
upper aerodigestive	19/22
urinary tract	21/29
uterus	3/5

Expression Distribution

PCI
RPN7

protein deneddylation
GTPase inhibitor activity
nucleotide-excision repair, DNA damage recognition
inactivation of MAPK activity
COP9 signalosome
negative regulation of GTPase activity
transcription-coupled nucleotide-excision repair
negative regulation of MAP kinase activity
JNK cascade
stress-activated MAPK cascade
nucleotide-excision repair
negative regulation of protein serine/threonine kinase activity
stress-activated protein kinase signaling cascade
negative regulation of MAPK cascade
negative regulation of protein kinase activity
negative regulation of kinase activity
negative regulation of transferase activity
protein modification by small protein removal
regulation of MAP kinase activity
post-translational protein modification
MAPK cascade
signal transduction by protein phosphorylation
negative regulation of protein phosphorylation
negative regulation of phosphorylation
negative regulation of hydrolase activity
regulation of GTPase activity
negative regulation of intracellular signal transduction
DNA repair
regulation of protein serine/threonine kinase activity
negative regulation of phosphate metabolic process
negative regulation of phosphorus metabolic process
negative regulation of protein modification process
DNA metabolic process
regulation of MAPK cascade
cellular response to DNA damage stimulus
negative regulation of catalytic activity
regulation of protein kinase activity
regulation of kinase activity
protein phosphorylation
regulation of transferase activity