GRB10

Gene Information

Official Symbol: GRB10
Official Name: growth factor receptor bound protein 10
Aliases and Previous Symbols: N/A
Entrez ID: 2887
UniProt: Q13322
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: The product of this gene belongs to a small family of adapter proteins that are known to interact with a number of receptor tyrosine kinases and signaling molecules. This gene encodes a growth factor receptor-binding protein that interacts with insulin receptors and insulin-like growth-factor receptors. Overexpression of some isoforms of the encoded protein inhibits tyrosine kinase activity and results in growth suppression. This gene is imprinted in a highly isoform- and tissue-specific manner, with expression observed from the paternal allele in the brain, and from the maternal allele in the placental trophoblasts. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Oct 2010].
UniProt Summary: N/A

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Salinomycin 3.5μM R08 exp521	-1.78
Cidofovir 10μM R07 exp345	1.7
Vinblastine 0.015μM R05 exp208	1.79
BI-6727 0.04μM R03 exp98	1.8
Cytochalasin-B 5μM R07 exp349	1.88
Bortezomib 0.05μM R00 exp7	1.91
Nocodazole 0.2μM R00 exp24	2.8
SB743921 0.001μM R05 exp244	3.4

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 8557
Expression level (log2 read counts): 6.46

Expression Distribution

SH2
BPS
RA
PH

negative regulation of glucose import
positive regulation of vascular endothelial growth factor receptor signaling pathway
negative regulation of glucose transmembrane transport
insulin receptor binding
regulation of vascular endothelial growth factor receptor signaling pathway
negative regulation of insulin receptor signaling pathway
negative regulation of cellular response to insulin stimulus
SH3/SH2 adaptor activity
regulation of glucose import
regulation of insulin receptor signaling pathway
regulation of cellular response to insulin stimulus
regulation of glucose transmembrane transport
insulin receptor signaling pathway
positive regulation of cold-induced thermogenesis
negative regulation of transmembrane transport
regulation of cold-induced thermogenesis
cellular response to insulin stimulus
negative regulation of Wnt signaling pathway
response to insulin
axon guidance
neuron projection guidance
cellular response to peptide hormone stimulus
regulation of cellular response to growth factor stimulus
cellular response to peptide
regulation of Wnt signaling pathway
axonogenesis
response to peptide hormone
axon development
cell morphogenesis involved in neuron differentiation
response to peptide
neuron projection morphogenesis
plasma membrane bounded cell projection morphogenesis
negative regulation of transport
cell projection morphogenesis
transmembrane receptor protein tyrosine kinase signaling pathway
cell part morphogenesis
chemotaxis
taxis
cell morphogenesis involved in differentiation
regulation of transmembrane transport