GSX1

Entrez Summary: N/A
UniProt Summary: Probable transcription factor that binds to the DNA sequence 5'-GC[TA][AC]ATTA[GA]-3'. Activates the transcription of the GHRH gene. Plays an important role in pituitary development.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
DKK1 89ng/ml R08 exp477	1.83
IU1-47 25μM R04 exp182	2.03

adenohypophysis development
spinal cord association neuron differentiation
RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding
hypothalamus development
dorsal spinal cord development
pituitary gland development
cell differentiation in spinal cord
neuron fate commitment
diencephalon development
spinal cord development
limbic system development
endocrine system development
central nervous system neuron differentiation
DNA-binding transcription repressor activity, RNA polymerase II-specific
cell fate commitment
forebrain development
gland development
sequence-specific DNA binding
DNA-binding transcription activator activity, RNA polymerase II-specific
RNA polymerase II proximal promoter sequence-specific DNA binding
brain development
head development
central nervous system development
neuron differentiation
positive regulation of transcription by RNA polymerase II
generation of neurons
positive regulation of transcription, DNA-templated
DNA-binding transcription factor activity, RNA polymerase II-specific
neurogenesis
positive regulation of nucleic acid-templated transcription
positive regulation of RNA biosynthetic process
positive regulation of RNA metabolic process
positive regulation of nucleobase-containing compound metabolic process
positive regulation of macromolecule biosynthetic process
positive regulation of cellular biosynthetic process
positive regulation of gene expression
positive regulation of biosynthetic process