HMG20B

Entrez Summary: N/A
UniProt Summary: Required for correct progression through G2 phase of the cell cycle and entry into mitosis. Required for RCOR1/CoREST mediated repression of neuronal specific gene promoters.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/25
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/15
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/14
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/7
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

negative regulation of protein sumoylation
regulation of protein sumoylation
skeletal muscle cell differentiation
negative regulation of protein modification by small protein conjugation or removal
chromosome
skeletal muscle tissue development
skeletal muscle organ development
regulation of protein modification by small protein conjugation or removal
nuclear body
striated muscle tissue development
blood coagulation
coagulation
muscle organ development
muscle tissue development
hemostasis
positive regulation of neuron differentiation
positive regulation of neurogenesis
muscle structure development
wound healing
protein heterodimerization activity
regulation of body fluid levels
positive regulation of nervous system development
positive regulation of cell development
response to wounding
negative regulation of protein modification process
regulation of neuron differentiation
chromatin organization
regulation of neurogenesis
regulation of nervous system development
regulation of cell development
positive regulation of cell differentiation
negative regulation of cellular protein metabolic process
chromosome organization
negative regulation of protein metabolic process
cell cycle
positive regulation of developmental process
DNA binding
generation of neurons
DNA-binding transcription factor activity, RNA polymerase II-specific
neurogenesis