KLLN

Gene Information
  • Official Symbol: KLLN
  • Official Name: killin, p53 regulated DNA replication inhibitor
  • Aliases and Previous Symbols: N/A
  • Entrez ID: 100144748
  • UniProt: B2CW77
  • Interactions: BioGRID
  • PubMed articles: Open PubMed
  • OMIM: Open OMIM
Function Summary
  • Entrez Summary: The protein encoded by this intronless gene is found in the nucleus, where it can inhibit DNA synthesis and promote S phase arrest coupled to apoptosis. The expression of this DNA binding protein is upregulated by transcription factor p53. [provided by RefSeq, Dec 2012].
  • UniProt Summary: DNA-binding protein involved in S phase checkpoint control-coupled apoptosis by mediating p53/TP53-induced apoptosis. Has the ability to inhibit DNA synthesis and S phase arrest coupled to apoptosis. Has affinity to both double- and single- stranded DNA. {ECO:0000269|PubMed:18385383}.

Pfam Domains GO Terms


CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Essentiality in NALM6
  • Essentiality Rank: 5344
  • Expression level (log2 read counts): 2.77

Expression Distribution

  • Last modified: 2025/12/10 20:19
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