LDHA

Entrez Summary: The protein encoded by this gene catalyzes the conversion of L-lactate and NAD to pyruvate and NADH in the final step of anaerobic glycolysis. The protein is found predominantly in muscle tissue and belongs to the lactate dehydrogenase family. Mutations in this gene have been linked to exertional myoglobinuria. Multiple transcript variants encoding different isoforms have been found for this gene. The human genome contains several non-transcribed pseudogenes of this gene. [provided by RefSeq, Sep 2008].
UniProt Summary: N/A

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 1/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Ldh 1 N
Ldh 1 C

L-lactate dehydrogenase activity
lactate metabolic process
post-embryonic animal organ development
NAD binding
glycolytic process
ATP generation from ADP
NAD metabolic process
ADP metabolic process
nucleoside diphosphate phosphorylation
purine nucleoside diphosphate metabolic process
purine ribonucleoside diphosphate metabolic process
nucleotide phosphorylation
ribonucleoside diphosphate metabolic process
pyruvate metabolic process
response to estrogen
nucleoside diphosphate metabolic process
kinase binding
response to cAMP
response to hydrogen peroxide
carbohydrate catabolic process
response to organophosphorus
response to glucose
response to hexose
response to monosaccharide
response to purine-containing compound
response to carbohydrate
response to reactive oxygen species
ATP metabolic process
response to nutrient
response to antibiotic
cadherin binding
purine ribonucleotide metabolic process
ribonucleotide metabolic process
purine nucleotide metabolic process
ribose phosphate metabolic process
response to hypoxia
response to decreased oxygen levels
purine-containing compound metabolic process
response to oxygen levels
response to oxidative stress