LPIN1

Entrez Summary: This gene encodes a magnesium-ion-dependent phosphatidic acid phosphohydrolase enzyme that catalyzes the penultimate step in triglyceride synthesis including the dephosphorylation of phosphatidic acid to yield diacylglycerol. Expression of this gene is required for adipocyte differentiation and it also functions as a nuclear transcriptional coactivator with some peroxisome proliferator-activated receptors to modulate expression of other genes involved in lipid metabolism. Mutations in this gene are associated with metabolic syndrome, type 2 diabetes, acute recurrent rhabdomyolysis, and autosomal recessive acute recurrent myoglobinuria (ARARM). This gene is also a candidate for several human lipodystrophy syndromes. [provided by RefSeq, Mar 2017]. COMPLETENESS: complete on the 3' end.
UniProt Summary: N/A

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
Rotenone 0.07μM R08 exp431	1.8
Phorbol-12-myristate-13-acetate 0.57μM R08 exp514	1.89

LNS2
Lipin N

triglyceride mobilization
mitotic nuclear envelope disassembly
phosphatidate phosphatase activity
phosphatidylethanolamine biosynthetic process
nuclear envelope disassembly
membrane disassembly
triglyceride biosynthetic process
neutral lipid biosynthetic process
acylglycerol biosynthetic process
phosphatidylethanolamine metabolic process
phosphatidylcholine biosynthetic process
nuclear envelope organization
animal organ regeneration
triglyceride metabolic process
phosphatidylcholine metabolic process
fatty acid catabolic process
positive regulation of cold-induced thermogenesis
acylglycerol metabolic process
neutral lipid metabolic process
monocarboxylic acid catabolic process
nucleus organization
regulation of cold-induced thermogenesis
regeneration
cellular response to insulin stimulus
mitochondrial outer membrane
nuclear envelope
ammonium ion metabolic process
cellular lipid catabolic process
glycerophospholipid biosynthetic process
glycerolipid biosynthetic process
response to insulin
nuclear membrane
phospholipid biosynthetic process
cellular response to peptide hormone stimulus
carboxylic acid catabolic process
organic acid catabolic process
transcription coactivator activity
lipid catabolic process
glycerophospholipid metabolic process
dephosphorylation