LRIG2

Gene Information

Official Symbol: LRIG2
Official Name: leucine rich repeats and immunoglobulin like domains 2
Aliases and Previous Symbols: N/A
Entrez ID: 9860
UniProt: O94898
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene encodes a transmembrane protein containing leucine-rich repeats and immunoglobulin-like domains. The encoded protein promotes epidermal growth factor signalling, resulting in increased proliferation. Its expression in the cytoplasm of glioma cells is correlated with poor survival. Mutations in this gene can cause urofacial syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015].
UniProt Summary: N/A

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 10978
Expression level (log2 read counts): 6.14

Expression Distribution

Screen	Score
RS-1 10μM R08 exp519	-2.51
A-366 10μM R03 exp115	2.18

LRR 4
I-set

intracellular vesicle
negative regulation of membrane protein ectodomain proteolysis
negative regulation of axon regeneration
negative regulation of neuron projection regeneration
positive regulation of protein localization to cell surface
regulation of platelet-derived growth factor receptor signaling pathway
regulation of membrane protein ectodomain proteolysis
regulation of axon regeneration
innervation
regulation of neuron projection regeneration
regulation of protein localization to cell surface
regulation of neuron migration
nerve development
negative regulation of response to wounding
growth cone
negative regulation of protein catabolic process
sensory perception of sound
negative regulation of neuron projection development
regulation of response to wounding
sensory perception of mechanical stimulus
negative regulation of cell projection organization
negative regulation of neuron differentiation
extracellular matrix
negative regulation of cellular catabolic process
negative regulation of neurogenesis
negative regulation of catabolic process
negative regulation of nervous system development
positive regulation of cellular protein localization
negative regulation of cell development
signaling receptor binding
negative regulation of proteolysis
negative regulation of response to external stimulus
neuronal cell body
regulation of protein catabolic process
regulation of neuron projection development
regulation of cellular protein localization
regulation of neuron differentiation
regulation of plasma membrane bounded cell projection organization
negative regulation of cellular component organization
regulation of cell projection organization