LYPLA2

Entrez Summary: N/A
UniProt Summary: Hydrolyzes fatty acids from S-acylated cysteine residues in proteins such as trimeric G alpha proteins, GAP43, ZDHHC6 or HRAS (PubMed:21152083, PubMed:28826475). Deacylates GAP43 (PubMed:21152083). Mediates depalmitoylation of ZDHHC6 (PubMed:28826475). Has lysophospholipase activity (By similarity). {ECO:0000250|UniProtKB:Q9WTL7, ECO:0000269|PubMed:21152083, ECO:0000269|PubMed:28826475}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
∆-9-Tetrahydrocannabinol 30μM R08 exp445	1.7
Aphidicolin 0.04μM R06 exp263	1.74
PNU96415E 10μM R03 exp145	1.76

protein depalmitoylation
macromolecule depalmitoylation
palmitoyl-(protein) hydrolase activity
lipoprotein catabolic process
carboxylic ester hydrolase activity
Golgi stack
protein deacylation
macromolecule deacylation
lipoprotein metabolic process
axon guidance
neuron projection guidance
cadherin binding
fatty acid metabolic process
axonogenesis
axon development
cell morphogenesis involved in neuron differentiation
neuron projection morphogenesis
plasma membrane bounded cell projection morphogenesis
cell projection morphogenesis
cell part morphogenesis
monocarboxylic acid metabolic process
chemotaxis
taxis
cell morphogenesis involved in differentiation
neuron projection development
protein catabolic process
cell morphogenesis
neuron development
cellular component morphogenesis
carboxylic acid metabolic process
cellular lipid metabolic process
oxoacid metabolic process
neuron differentiation
organic acid metabolic process
macromolecule catabolic process
organonitrogen compound catabolic process
plasma membrane bounded cell projection organization
cell projection organization
lipid metabolic process
locomotion