MAPK7

Gene Information

Official Symbol: MAPK7
Official Name: mitogen-activated protein kinase 7
Aliases and Previous Symbols: N/A
Entrez ID: 5598
UniProt: Q13164
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Plays a role in various cellular processes such as proliferation, differentiation and cell survival. The upstream activator of MAPK7 is the MAPK kinase MAP2K5. Upon activation, it translocates to the nucleus and phosphorylates various downstream targets including MEF2C. EGF activates MAPK7 through a Ras- independent and MAP2K5-dependent pathway. May have a role in muscle cell differentiation. May be important for endothelial function and maintenance of blood vessel integrity. MAP2K5 and MAPK7 interact specifically with one another and not with MEK1/ERK1 or MEK2/ERK2 pathways. Phosphorylates SGK1 at Ser-78 and this is required for growth factor-induced cell cycle progression. Involved in the regulation of p53/TP53 by disrupting the PML-MDM2 interaction. {ECO:0000269|PubMed:11254654, ECO:0000269|PubMed:11278431, ECO:0000269|PubMed:22869143, ECO:0000269|PubMed:9384584, ECO:0000269|PubMed:9790194}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Amiloride 100μM R08 exp447	-1.87
LB-100 2μM R05 exp210	-1.84
ML-792 0.2μM R08 exp505	-1.77
MS023 2μM R03 exp134	1.81
BI-6727 0.0125μM R03 exp97	1.91
Ammonium tetrathiomolybdate 10μM R08 exp448	2.08
Staurosporine 0.02μM R08 exp524	3.77

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 5723
Expression level (log2 read counts): 3.42

Expression Distribution

Pkinase Tyr
Pkinase

negative regulation of cyclic-nucleotide phosphodiesterase activity
cellular response to laminar fluid shear stress
regulation of cyclic-nucleotide phosphodiesterase activity
regulation of cell-cell adhesion involved in gastrulation
negative regulation of heterotypic cell-cell adhesion
negative regulation of calcineurin-NFAT signaling cascade
MAP kinase activity
negative regulation of calcineurin-mediated signaling
response to laminar fluid shear stress
cellular response to fluid shear stress
negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
mitogen-activated protein kinase binding
regulation of heterotypic cell-cell adhesion
regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
negative regulation of endothelial cell apoptotic process
negative regulation of calcium-mediated signaling
positive regulation of transcription from RNA polymerase II promoter in response to stress
response to fluid shear stress
regulation of calcineurin-NFAT signaling cascade
regulation of calcineurin-mediated signaling
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
negative regulation of signal transduction in absence of ligand
regulation of gastrulation
negative regulation of epithelial cell apoptotic process
negative regulation of oxidative stress-induced cell death
negative regulation of cellular response to oxidative stress
regulation of extrinsic apoptotic signaling pathway in absence of ligand
negative regulation of response to oxidative stress
regulation of endothelial cell apoptotic process
regulation of oxidative stress-induced cell death
negative regulation of response to cytokine stimulus
cellular response to hydrogen peroxide
regulation of cellular response to oxidative stress
regulation of epithelial cell apoptotic process
regulation of response to oxidative stress
negative regulation of intrinsic apoptotic signaling pathway
regulation of calcium-mediated signaling
PML body
negative regulation of extrinsic apoptotic signaling pathway
cellular response to antibiotic