MARCH6

Entrez Summary: N/A
UniProt Summary: E3 ubiquitin-protein ligase that promotes ubiquitination of DIO2, leading to its degradation. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. May cooperate with UBE2G1. {ECO:0000269|PubMed:15673284, ECO:0000269|PubMed:19651899}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 3/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	1/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

ER ubiquitin ligase complex
endoplasmic reticulum mannose trimming
ubiquitin-specific protease binding
protein alpha-1,2-demannosylation
protein demannosylation
endoplasmic reticulum quality control compartment
protein deglycosylation
ubiquitin conjugating enzyme binding
protein K48-linked ubiquitination
ubiquitin-dependent ERAD pathway
ERAD pathway
integral component of endoplasmic reticulum membrane
ubiquitin protein ligase activity
ubiquitin-protein transferase activity
response to endoplasmic reticulum stress
protein polyubiquitination
proteasome-mediated ubiquitin-dependent protein catabolic process
enzyme binding
proteasomal protein catabolic process
glycoprotein metabolic process
ubiquitin-dependent protein catabolic process
modification-dependent protein catabolic process
modification-dependent macromolecule catabolic process
proteolysis involved in cellular protein catabolic process
cellular protein catabolic process
protein catabolic process
protein ubiquitination
protein modification by small protein conjugation
zinc ion binding
cellular macromolecule catabolic process
endoplasmic reticulum membrane
protein modification by small protein conjugation or removal
response to organonitrogen compound
endoplasmic reticulum
carbohydrate derivative metabolic process
macromolecule catabolic process
organonitrogen compound catabolic process
response to nitrogen compound
proteolysis
cellular response to stress