MYL6

Entrez Summary: Myosin is a hexameric ATPase cellular motor protein. It is composed of two heavy chains, two nonphosphorylatable alkali light chains, and two phosphorylatable regulatory light chains. This gene encodes a myosin alkali light chain that is expressed in smooth muscle and non-muscle tissues. Genomic sequences representing several pseudogenes have been described and two transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jul 2008].
UniProt Summary: Regulatory light chain of myosin. Does not bind calcium.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
All-trans-Retinoic-Acid 40μM R07 exp334	1.76
Docosahexaenoic-acid 50μM R07 exp356	1.76
Rapamycin 2μM plus Cyclosporin-A 3μM R07 exp307	1.77
Trichostatin-A 0.06μM R07 exp415	1.8
Salubrinal 20μM R07 exp399	1.9
UM0129480 7μM R02 exp85	2.22
FK-506 5μM R07 exp358	2.31

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

unconventional myosin complex
actin-dependent ATPase activity
myosin complex
actin-myosin filament sliding
muscle filament sliding
motor activity
structural constituent of muscle
brush border
actin-mediated cell contraction
actin filament-based movement
skeletal muscle tissue development
skeletal muscle organ development
vesicle
muscle contraction
striated muscle tissue development
muscle organ development
muscle tissue development
muscle system process
muscle structure development
actin filament-based process
calcium ion binding
movement of cell or subcellular component
tissue development
system process
membrane